Agonist potency determination by patch clamp analysis of single glutamate receptors

Kenneth A. F. Gration, Jeremy J. Lambert, Robert L. Ramsey, R. Peter Rand, Peter N. R. Usherwood

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Agonists (l-quisqualate, l-glutamate and l-cysteine sulphinate) of the locust muscle glutamate receptor differ in potency. Patch clamp analysis of single glutamate receptors reveals that the relative potencies of agonists are determined both by the life-times of the channels that they gate and their probability of activating the glutamate receptor-ionophore complex. Furthermore, agonists which most readily activate the receptor channel complex gate channels with longer life-times than agonists which are less efficient in this respect.

Original languageEnglish
Pages (from-to)400-405
Number of pages6
JournalBrain Research
Issue number1-2
Publication statusPublished - 28 Dec 1981


  • agonist potency
  • glutamate agonist
  • glutamate channel
  • l-cysteine sulphinate
  • l-glutamate
  • l-quisqualate
  • patch clamp analysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology


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