Airway and systemic effects of hydrofluoroalkane fluticasone and beclomethasone in patients with asthma

G P Currie, S J Fowler, A M Wilson, E J Sims, L C Orr, B J Lipworth

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Background: With the transition to hydrofluoroalkane-134a propellants in metered dose inhalers, it is
    important to consider the efficacy and safety profiles of formulations containing inhaled corticosteroids.
    We examined the airway and systemic effects of hydrofluoroalkane-134a fluticasone propionate (FLUHFA)
    and beclomethasone dipropionate (BEC-HFA) at recommended labelled doses.
    Methods: Twenty mild to moderate asthmatics were randomised in crossover fashion to receive 6
    weeks of 500 µg/day followed by 1000 µg/day FLU-HFA and BEC-HFA. Measurements were made
    at baseline after placebo run in and washout, and after each randomised treatment. The primary airway
    outcome for benefit was the dose of methacholine provoking a fall in forced expiratory volume in
    1 second (FEV1) of 20% or more (methacholine PD20) and for systemic adverse effects was overnight urinary
    cortisol/creatinine (OUCC).
    Results: For mean responses, both doses of BEC-HFA and FLU-HFA produced significant improvements
    in PD20 compared with baseline. The improvement was not significantly greater with 1000 µg/day
    FLU-HFA versus BEC-HFA, a 1.69 fold difference (95% CI 0.94 to 3.04). Both doses of BEC-HFA but
    not FLU-HFA caused significant suppression of OUCC compared with baseline, with significantly
    (p<0.05) lower values at 1000 µg/day for BEC-HFA versus FLU-HFA (1.97 fold difference (95% CI
    1.28 to 3.02)).
    Conclusion: There was no difference in the airway and systemic effects in patients with mild to moderate
    asthma between FLU-HFA and BEC-HFA at a dose of 500 µg/day. At 1000 µg/day there was
    increased systemic bioactivity with BEC-HFA compared with FLU-HFA, without any gain in airway efficacy.
    Original languageEnglish
    Pages (from-to)865-8
    Number of pages4
    JournalThorax
    Volume57
    Issue number10
    DOIs
    Publication statusPublished - 2002

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