Alcohol and cancer risk: A systematic review and meta-analysis of prospective Indian studies

Hitesh Rajendra Singhavi; Arjun Singh; Atanu Bhattacharjee; Sanjay Talole; Rajesh Dikshit; Pankaj Chaturvedi

doi:10.4103/ijph.IJPH_529_19

Alcohol and cancer risk: A systematic review and meta-analysis of prospective Indian studies

Hitesh Rajendra Singhavi
, Arjun Singh
, Atanu Bhattacharjee (Lead / Corresponding author)
, Sanjay Talole
, Rajesh Dikshit
, Pankaj Chaturvedi

Population Health and Genomics

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

76 Downloads (Pure)

Abstract

Background:
Alcohol increases risk of cancer of oral cavity and pharynx, esophagus, colorectal, liver, larynx, and female breast.
Objectives:
The objective of this study was to determine the relationship of alcohol and cancer in India by meta-analysis.
Methods:
Systematic Medline searches were performed to identify all the published literature associating alcohol and cancer in India. Initially, we retrieved 1509 studies, but after applying inclusion and exclusion criteria, only 29 studies were found eligible for our meta-analysis.
Results:
Our meta-analysis shows that alcohol consumption increases the risk of cancer with the odds ratio (OR) of 2.32 (95% confidence interval [CI]: 1.50–3.47) in case–control studies and relative risk of 1.52 (95% CI: 0.97–2.51) in cohort studies. It also shows that risk of oral cavity cancer increases by two times (OR: 1.92, 95% CI: 1.54–3.96) in the population consuming alcohol. Publication analysis showed that studies included in the meta-analysis had wide variation, suggesting good representation all over the country.
Conclusion:
The result from our meta-analysis supports our hypothesis that alcohol consumption increases the risk of cancer, implying immediate cessation of the habit for cancer risk reduction.

Original language	English
Pages (from-to)	186 - 190
Number of pages	8
Journal	Indian journal of public health
Volume	64
Issue number	2
DOIs	https://doi.org/10.4103/ijph.IJPH_529_19
Publication status	Published - 16 Jun 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alcohol
cancer risk
India
meta-analysis

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10.4103/ijph.IJPH_529_19Licence: CC BY-NC-SA

Final published versionFinal published version, 803 KBLicence: CC BY-NC-SA

Cite this

@article{e2559af26f5a441991632cd4ec9a62a3,

title = "Alcohol and cancer risk: A systematic review and meta-analysis of prospective Indian studies",

abstract = "Background: Alcohol increases risk of cancer of oral cavity and pharynx, esophagus, colorectal, liver, larynx, and female breast. Objectives: The objective of this study was to determine the relationship of alcohol and cancer in India by meta-analysis. Methods: Systematic Medline searches were performed to identify all the published literature associating alcohol and cancer in India. Initially, we retrieved 1509 studies, but after applying inclusion and exclusion criteria, only 29 studies were found eligible for our meta-analysis. Results: Our meta-analysis shows that alcohol consumption increases the risk of cancer with the odds ratio (OR) of 2.32 (95\% confidence interval [CI]: 1.50{\textendash}3.47) in case{\textendash}control studies and relative risk of 1.52 (95\% CI: 0.97{\textendash}2.51) in cohort studies. It also shows that risk of oral cavity cancer increases by two times (OR: 1.92, 95\% CI: 1.54{\textendash}3.96) in the population consuming alcohol. Publication analysis showed that studies included in the meta-analysis had wide variation, suggesting good representation all over the country. Conclusion: The result from our meta-analysis supports our hypothesis that alcohol consumption increases the risk of cancer, implying immediate cessation of the habit for cancer risk reduction.",

keywords = "Alcohol, cancer risk, India, meta-analysis",

author = "Singhavi, \{Hitesh Rajendra\} and Arjun Singh and Atanu Bhattacharjee and Sanjay Talole and Rajesh Dikshit and Pankaj Chaturvedi",

note = "{\textcopyright} 2020 Indian Journal of Public Health | Published by Wolters Kluwer - Medknow",

year = "2020",

month = jun,

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doi = "10.4103/ijph.IJPH\_529\_19",

language = "English",

volume = "64",

pages = "186 -- 190",

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TY - JOUR

T1 - Alcohol and cancer risk

T2 - A systematic review and meta-analysis of prospective Indian studies

AU - Singhavi, Hitesh Rajendra

AU - Singh, Arjun

AU - Bhattacharjee, Atanu

AU - Talole, Sanjay

AU - Dikshit, Rajesh

AU - Chaturvedi, Pankaj

PY - 2020/6/16

Y1 - 2020/6/16

N2 - Background: Alcohol increases risk of cancer of oral cavity and pharynx, esophagus, colorectal, liver, larynx, and female breast. Objectives: The objective of this study was to determine the relationship of alcohol and cancer in India by meta-analysis. Methods: Systematic Medline searches were performed to identify all the published literature associating alcohol and cancer in India. Initially, we retrieved 1509 studies, but after applying inclusion and exclusion criteria, only 29 studies were found eligible for our meta-analysis. Results: Our meta-analysis shows that alcohol consumption increases the risk of cancer with the odds ratio (OR) of 2.32 (95% confidence interval [CI]: 1.50–3.47) in case–control studies and relative risk of 1.52 (95% CI: 0.97–2.51) in cohort studies. It also shows that risk of oral cavity cancer increases by two times (OR: 1.92, 95% CI: 1.54–3.96) in the population consuming alcohol. Publication analysis showed that studies included in the meta-analysis had wide variation, suggesting good representation all over the country. Conclusion: The result from our meta-analysis supports our hypothesis that alcohol consumption increases the risk of cancer, implying immediate cessation of the habit for cancer risk reduction.

AB - Background: Alcohol increases risk of cancer of oral cavity and pharynx, esophagus, colorectal, liver, larynx, and female breast. Objectives: The objective of this study was to determine the relationship of alcohol and cancer in India by meta-analysis. Methods: Systematic Medline searches were performed to identify all the published literature associating alcohol and cancer in India. Initially, we retrieved 1509 studies, but after applying inclusion and exclusion criteria, only 29 studies were found eligible for our meta-analysis. Results: Our meta-analysis shows that alcohol consumption increases the risk of cancer with the odds ratio (OR) of 2.32 (95% confidence interval [CI]: 1.50–3.47) in case–control studies and relative risk of 1.52 (95% CI: 0.97–2.51) in cohort studies. It also shows that risk of oral cavity cancer increases by two times (OR: 1.92, 95% CI: 1.54–3.96) in the population consuming alcohol. Publication analysis showed that studies included in the meta-analysis had wide variation, suggesting good representation all over the country. Conclusion: The result from our meta-analysis supports our hypothesis that alcohol consumption increases the risk of cancer, implying immediate cessation of the habit for cancer risk reduction.

KW - Alcohol

KW - cancer risk

KW - India

KW - meta-analysis

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U2 - 10.4103/ijph.IJPH_529_19

DO - 10.4103/ijph.IJPH_529_19

M3 - Article

SN - 0019-557X

VL - 64

SP - 186

EP - 190

JO - Indian journal of public health

JF - Indian journal of public health

IS - 2

ER -

Alcohol and cancer risk: A systematic review and meta-analysis of prospective Indian studies

Abstract

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Keywords

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