Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients

Robert J. MacFadyen; Craig S. Barr; Allan D. Struthers

doi:10.1016/S0008-6363(97)00091-6

Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients

Robert J. MacFadyen, Craig S. Barr, Allan D. Struthers

Research output: Contribution to journal › Article › peer-review

329 Citations (Scopus)

Abstract

Experimental data suggest that aldosterone has harmful effects promoting myocardial fibrosis and disturbing autonomic balance. There has been no evidence of these potential effects in intact man.

Original language	English
Pages (from-to)	30-4
Number of pages	5
Journal	Cardiovascular Research
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/S0008-6363(97)00091-6
Publication status	Published - Jul 1997

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title = "Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients",

abstract = "Experimental data suggest that aldosterone has harmful effects promoting myocardial fibrosis and disturbing autonomic balance. There has been no evidence of these potential effects in intact man.",

author = "MacFadyen, {Robert J.} and Barr, {Craig S.} and Struthers, {Allan D.}",

year = "1997",

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language = "English",

volume = "35",

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T1 - Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients

AU - MacFadyen, Robert J.

AU - Barr, Craig S.

AU - Struthers, Allan D.

PY - 1997/7

Y1 - 1997/7

N2 - Experimental data suggest that aldosterone has harmful effects promoting myocardial fibrosis and disturbing autonomic balance. There has been no evidence of these potential effects in intact man.

AB - Experimental data suggest that aldosterone has harmful effects promoting myocardial fibrosis and disturbing autonomic balance. There has been no evidence of these potential effects in intact man.

U2 - 10.1016/S0008-6363(97)00091-6

DO - 10.1016/S0008-6363(97)00091-6

M3 - Article

C2 - 9302344

SN - 0008-6363

VL - 35

SP - 30

EP - 34

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 1

ER -

Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients

Abstract

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