Aldosterone blunts the baroreflex response in man

K. M. Yee, A. D. Struthers

    Research output: Contribution to journalArticle

    82 Citations (Scopus)

    Abstract

    1. Recent animal evidence suggests that aldosterone, like angiotensin II, may possess detrimental autonomic modulating properties. Aldosterone has been shown to impair the baroreflex response in animal models. This study is designed to test the hypothesis that aldosterone directly attenuates the baroreflex in vivo in man.

    2. Fourteen healthy male volunteers [mean age (S.D.) 25 (9) years] received intravenous daldosterone (12 pmol·min-1·kg-1) and 5% dextrose (vehicle) in a double-blind crossover fashion, co-infused with incremental doses of intravenous phenylephrine and sodium nitroprusside. Aldosterone had no significant effect on resting blood pressure, heart rate or baroreflex response to sodium nitroprusside. However, reflex responses to phenylephrine were impaired
    with aldosterone (P<0.01) while blood pressure responses were unaltered. Baroreflex sensitivity was significantly blunted in the aldosterone group [8.36±2.19 versus 10.12± 2.27 ms/mmHg; P<0.04].

    3. This study confirms previous observations from animal models that aldosterone impairs the baroreflex response. High aldosterone levels may contribute to the baroreflex dysfunction in cardiovascular diseases such as hypertension and heart failure.

    Original languageEnglish
    Pages (from-to)687-92
    Number of pages6
    JournalClinical Science
    Volume95
    Issue number6
    Publication statusPublished - 1998

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