Aldosterone blunts the baroreflex response in man

K. M. Yee, A. D. Struthers

    Research output: Contribution to journalArticle

    82 Citations (Scopus)

    Abstract

    1. Recent animal evidence suggests that aldosterone, like angiotensin II, may possess detrimental autonomic modulating properties. Aldosterone has been shown to impair the baroreflex response in animal models. This study is designed to test the hypothesis that aldosterone directly attenuates the baroreflex in vivo in man.

    2. Fourteen healthy male volunteers [mean age (S.D.) 25 (9) years] received intravenous daldosterone (12 pmol·min-1·kg-1) and 5% dextrose (vehicle) in a double-blind crossover fashion, co-infused with incremental doses of intravenous phenylephrine and sodium nitroprusside. Aldosterone had no significant effect on resting blood pressure, heart rate or baroreflex response to sodium nitroprusside. However, reflex responses to phenylephrine were impaired
    with aldosterone (P<0.01) while blood pressure responses were unaltered. Baroreflex sensitivity was significantly blunted in the aldosterone group [8.36±2.19 versus 10.12± 2.27 ms/mmHg; P<0.04].

    3. This study confirms previous observations from animal models that aldosterone impairs the baroreflex response. High aldosterone levels may contribute to the baroreflex dysfunction in cardiovascular diseases such as hypertension and heart failure.

    Original languageEnglish
    Pages (from-to)687-92
    Number of pages6
    JournalClinical Science
    Volume95
    Issue number6
    Publication statusPublished - 1998

    Fingerprint

    Baroreflex
    Aldosterone
    Nitroprusside
    Phenylephrine
    Animal Models
    Blood Pressure
    Angiotensin II
    Reflex
    Healthy Volunteers
    Cardiovascular Diseases
    Heart Failure
    Heart Rate
    Hypertension
    Glucose

    Cite this

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    title = "Aldosterone blunts the baroreflex response in man",
    abstract = "1. Recent animal evidence suggests that aldosterone, like angiotensin II, may possess detrimental autonomic modulating properties. Aldosterone has been shown to impair the baroreflex response in animal models. This study is designed to test the hypothesis that aldosterone directly attenuates the baroreflex in vivo in man. 2. Fourteen healthy male volunteers [mean age (S.D.) 25 (9) years] received intravenous daldosterone (12 pmol·min-1·kg-1) and 5{\%} dextrose (vehicle) in a double-blind crossover fashion, co-infused with incremental doses of intravenous phenylephrine and sodium nitroprusside. Aldosterone had no significant effect on resting blood pressure, heart rate or baroreflex response to sodium nitroprusside. However, reflex responses to phenylephrine were impaired with aldosterone (P<0.01) while blood pressure responses were unaltered. Baroreflex sensitivity was significantly blunted in the aldosterone group [8.36±2.19 versus 10.12± 2.27 ms/mmHg; P<0.04]. 3. This study confirms previous observations from animal models that aldosterone impairs the baroreflex response. High aldosterone levels may contribute to the baroreflex dysfunction in cardiovascular diseases such as hypertension and heart failure.",
    author = "Yee, {K. M.} and Struthers, {A. D.}",
    year = "1998",
    language = "English",
    volume = "95",
    pages = "687--92",
    journal = "Clinical Science",
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    }

    Aldosterone blunts the baroreflex response in man. / Yee, K. M.; Struthers, A. D.

    In: Clinical Science, Vol. 95, No. 6, 1998, p. 687-92.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Aldosterone blunts the baroreflex response in man

    AU - Yee, K. M.

    AU - Struthers, A. D.

    PY - 1998

    Y1 - 1998

    N2 - 1. Recent animal evidence suggests that aldosterone, like angiotensin II, may possess detrimental autonomic modulating properties. Aldosterone has been shown to impair the baroreflex response in animal models. This study is designed to test the hypothesis that aldosterone directly attenuates the baroreflex in vivo in man. 2. Fourteen healthy male volunteers [mean age (S.D.) 25 (9) years] received intravenous daldosterone (12 pmol·min-1·kg-1) and 5% dextrose (vehicle) in a double-blind crossover fashion, co-infused with incremental doses of intravenous phenylephrine and sodium nitroprusside. Aldosterone had no significant effect on resting blood pressure, heart rate or baroreflex response to sodium nitroprusside. However, reflex responses to phenylephrine were impaired with aldosterone (P<0.01) while blood pressure responses were unaltered. Baroreflex sensitivity was significantly blunted in the aldosterone group [8.36±2.19 versus 10.12± 2.27 ms/mmHg; P<0.04]. 3. This study confirms previous observations from animal models that aldosterone impairs the baroreflex response. High aldosterone levels may contribute to the baroreflex dysfunction in cardiovascular diseases such as hypertension and heart failure.

    AB - 1. Recent animal evidence suggests that aldosterone, like angiotensin II, may possess detrimental autonomic modulating properties. Aldosterone has been shown to impair the baroreflex response in animal models. This study is designed to test the hypothesis that aldosterone directly attenuates the baroreflex in vivo in man. 2. Fourteen healthy male volunteers [mean age (S.D.) 25 (9) years] received intravenous daldosterone (12 pmol·min-1·kg-1) and 5% dextrose (vehicle) in a double-blind crossover fashion, co-infused with incremental doses of intravenous phenylephrine and sodium nitroprusside. Aldosterone had no significant effect on resting blood pressure, heart rate or baroreflex response to sodium nitroprusside. However, reflex responses to phenylephrine were impaired with aldosterone (P<0.01) while blood pressure responses were unaltered. Baroreflex sensitivity was significantly blunted in the aldosterone group [8.36±2.19 versus 10.12± 2.27 ms/mmHg; P<0.04]. 3. This study confirms previous observations from animal models that aldosterone impairs the baroreflex response. High aldosterone levels may contribute to the baroreflex dysfunction in cardiovascular diseases such as hypertension and heart failure.

    M3 - Article

    VL - 95

    SP - 687

    EP - 692

    JO - Clinical Science

    JF - Clinical Science

    SN - 0143-5221

    IS - 6

    ER -