Aldosterone in heart failure: pathophysiology and treatment

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    Abstract

    Aldosterone produces adverse effects on the vasculature (endothelial dysfunction) and on the myocardium (myocardial fibrosis). These effects have adverse clinical consequences that result in increases in deaths caused by sudden death and by progressive heart failure. The Randomized Aldactone Evaluation Study and the Eplerenone Post-acute Myocardial Infarction Heart Failure Efficacy and Survival Study show this clearly. Aldosterone blockade should become a regular third neuroendocrine-blocking drug in patients with chronic heart failure.
    Original languageEnglish
    Pages (from-to)171-175
    Number of pages5
    JournalCurrent Heart Failure Reports
    Volume1
    Issue number4
    Publication statusPublished - 2004

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