Aldosterone-induced vasculopathy

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    31 Citations (Scopus)

    Abstract

    Aldosterone antagonists reduce mortality in chronic heart failure (CHF). An obvious question to ask is how do they do this. The prevailing hypothesis is that most of the adverse effects of aldosterone stem from its ability to produce a vasculopathy. This vasculopathy is characterised by a reduction in vascular nitric oxide and may be produced by aldosterone's ability to generate superoxide radicals which degrade endogenous NO. The consequences of this "aldosterone-induced vasculopathy" are that it produces tissue ischaemia/infarction and injury, which then repairs itself by producing fibrosis. "Aldosterone-induced vasculopathy" may be the main mechanism why aldosterone promotes widespread tissue injury and ultimately cardiac death.
    Original languageEnglish
    Pages (from-to)239-41
    Number of pages3
    JournalMolecular and Cellular Endocrinology
    Volume217
    Issue number1-2
    DOIs
    Publication statusPublished - 2004
    EventInternational symposium on aldosterone - London, United Kingdom
    Duration: 28 Apr 200330 Apr 2003

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