Alkoxy-functionalised dihydropyrimido[4,5-b]quinolinones enabling anti-proliferative and anti-invasive agents

Subham G. Patel; Ira Sharma; Mehul P. Parmar; Joaquina Nogales; Chirag D. Patel; Savan S. Bhalodiya; Disha P. Vala; Niraj V. Shah; Sourav Banerjee; Hitendra M. Patel

doi:10.1039/d4cc01219d

Alkoxy-functionalised dihydropyrimido[4,5-b]quinolinones enabling anti-proliferative and anti-invasive agents

Subham G. Patel
, Ira Sharma
, Mehul P. Parmar
, Joaquina Nogales
, Chirag D. Patel
, Savan S. Bhalodiya
, Disha P. Vala
, Niraj V. Shah
, Sourav Banerjee (Lead / Corresponding author)
, Hitendra M. Patel (Lead / Corresponding author)

Cancer Research

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

126 Downloads (Pure)

Abstract

In this communication, we explored the synthesis of novel alkoxy-functionalised dihydropyrimido[4,5-b]quinolinones using a microwave-assisted multicomponent reaction. All the synthesized molecules were screened for anti-proliferative and anti-invasive activity against glioblastoma cells. 5c shows the most potent anti-proliferative activity with a half maximal effective concentration of less than 3 μM against primary patient-derived glioblastoma cells. 5c effectively inhibited invasion and tumor growth of 3D primary glioma cultures in a basement membrane matrix. This suggests that the novel compounds could inhibit both the proliferation and invasive spread of glioma and they were selected for further study.

Original language	English
Pages (from-to)	7093-7096
Number of pages	4
Journal	Chemical Communications
Issue number	55
DOIs	https://doi.org/10.1039/d4cc01219d
Publication status	Published - 20 Jun 2024

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/d4cc01219d

Author Accepted ManuscriptAccepted author manuscript, 1.28 MB

A Single Kinase Modulates The Diverse Extracellular Phosphoproteome Of Glioblastoma Multiforme
Banerjee, S. (Investigator)
1/08/22 → 31/07/26
Project: Research

Cite this

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title = "Alkoxy-functionalised dihydropyrimido[4,5-b]quinolinones enabling anti-proliferative and anti-invasive agents",

abstract = "In this communication, we explored the synthesis of novel alkoxy-functionalised dihydropyrimido[4,5-b]quinolinones using a microwave-assisted multicomponent reaction. All the synthesized molecules were screened for anti-proliferative and anti-invasive activity against glioblastoma cells. 5c shows the most potent anti-proliferative activity with a half maximal effective concentration of less than 3 μM against primary patient-derived glioblastoma cells. 5c effectively inhibited invasion and tumor growth of 3D primary glioma cultures in a basement membrane matrix. This suggests that the novel compounds could inhibit both the proliferation and invasive spread of glioma and they were selected for further study.",

author = "Patel, \{Subham G.\} and Ira Sharma and Parmar, \{Mehul P.\} and Joaquina Nogales and Patel, \{Chirag D.\} and Bhalodiya, \{Savan S.\} and Vala, \{Disha P.\} and Shah, \{Niraj V.\} and Sourav Banerjee and Patel, \{Hitendra M.\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Royal Society of Chemistry.",

year = "2024",

month = jun,

day = "20",

doi = "10.1039/d4cc01219d",

language = "English",

pages = "7093--7096",

journal = "Chemical Communications",

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T1 - Alkoxy-functionalised dihydropyrimido[4,5-b]quinolinones enabling anti-proliferative and anti-invasive agents

AU - Patel, Subham G.

AU - Sharma, Ira

AU - Parmar, Mehul P.

AU - Nogales, Joaquina

AU - Patel, Chirag D.

AU - Bhalodiya, Savan S.

AU - Vala, Disha P.

AU - Shah, Niraj V.

AU - Banerjee, Sourav

AU - Patel, Hitendra M.

PY - 2024/6/20

Y1 - 2024/6/20

N2 - In this communication, we explored the synthesis of novel alkoxy-functionalised dihydropyrimido[4,5-b]quinolinones using a microwave-assisted multicomponent reaction. All the synthesized molecules were screened for anti-proliferative and anti-invasive activity against glioblastoma cells. 5c shows the most potent anti-proliferative activity with a half maximal effective concentration of less than 3 μM against primary patient-derived glioblastoma cells. 5c effectively inhibited invasion and tumor growth of 3D primary glioma cultures in a basement membrane matrix. This suggests that the novel compounds could inhibit both the proliferation and invasive spread of glioma and they were selected for further study.

AB - In this communication, we explored the synthesis of novel alkoxy-functionalised dihydropyrimido[4,5-b]quinolinones using a microwave-assisted multicomponent reaction. All the synthesized molecules were screened for anti-proliferative and anti-invasive activity against glioblastoma cells. 5c shows the most potent anti-proliferative activity with a half maximal effective concentration of less than 3 μM against primary patient-derived glioblastoma cells. 5c effectively inhibited invasion and tumor growth of 3D primary glioma cultures in a basement membrane matrix. This suggests that the novel compounds could inhibit both the proliferation and invasive spread of glioma and they were selected for further study.

U2 - 10.1039/d4cc01219d

DO - 10.1039/d4cc01219d

M3 - Article

C2 - 38899811

AN - SCOPUS:85196721258

SN - 1359-7345

SP - 7093

EP - 7096

JO - Chemical Communications

JF - Chemical Communications

IS - 55

ER -

Alkoxy-functionalised dihydropyrimido[4,5-b]quinolinones enabling anti-proliferative and anti-invasive agents

Abstract

ASJC Scopus subject areas

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A Single Kinase Modulates The Diverse Extracellular Phosphoproteome Of Glioblastoma Multiforme

Cite this