Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia

M. F. Evans, J. Koreth, C. J. Bakkenist, C. S. Herrington, J. O'D. McGee

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. GIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six tone with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.

    Original languageEnglish
    Pages (from-to)2557-2564
    Number of pages8
    JournalOncogene
    Volume16
    Issue number19
    Publication statusPublished - 1998

    Cite this

    Evans, M. F., Koreth, J., Bakkenist, C. J., Herrington, C. S., & McGee, J. OD. (1998). Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia. Oncogene, 16(19), 2557-2564.
    Evans, M. F. ; Koreth, J. ; Bakkenist, C. J. ; Herrington, C. S. ; McGee, J. O'D. / Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia. In: Oncogene. 1998 ; Vol. 16, No. 19. pp. 2557-2564.
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    title = "Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia",
    abstract = "Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. GIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7{\%}) had 11q23.3-q25 deletions; focally intra-lesional in six tone with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.",
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    Evans, MF, Koreth, J, Bakkenist, CJ, Herrington, CS & McGee, JOD 1998, 'Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia', Oncogene, vol. 16, no. 19, pp. 2557-2564.

    Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia. / Evans, M. F.; Koreth, J.; Bakkenist, C. J.; Herrington, C. S. ; McGee, J. O'D.

    In: Oncogene, Vol. 16, No. 19, 1998, p. 2557-2564.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia

    AU - Evans, M. F.

    AU - Koreth, J.

    AU - Bakkenist, C. J.

    AU - Herrington, C. S.

    AU - McGee, J. O'D.

    PY - 1998

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    N2 - Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. GIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six tone with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.

    AB - Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. GIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six tone with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.

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    VL - 16

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    JO - Oncogene

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    SN - 0950-9232

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    Evans MF, Koreth J, Bakkenist CJ, Herrington CS, McGee JOD. Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia. Oncogene. 1998;16(19):2557-2564.