Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia

M. F. Evans; J. Koreth; C. J. Bakkenist; C. S.  Herrington; J. O'D. McGee

Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia

M. F. Evans
, J. Koreth
, C. J. Bakkenist
, C. S. Herrington
, J. O'D. McGee

Research output: Contribution to journal › Article › peer-review

Abstract

Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. GIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six tone with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.

Original language	English
Pages (from-to)	2557-2564
Number of pages	8
Journal	Oncogene
Volume	16
Issue number	19
Publication status	Published - 1998

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@article{ee7d358bf37d403996e1a5ac693046d7,

title = "Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia",

abstract = "Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. GIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7\%) had 11q23.3-q25 deletions; focally intra-lesional in six tone with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.",

author = "Evans, \{M. F.\} and J. Koreth and Bakkenist, \{C. J.\} and Herrington, \{C. S.\} and McGee, \{J. O'D.\}",

year = "1998",

language = "English",

volume = "16",

pages = "2557--2564",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Springer Nature",

number = "19",

}

TY - JOUR

T1 - Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia

AU - Evans, M. F.

AU - Koreth, J.

AU - Bakkenist, C. J.

AU - Herrington, C. S.

AU - McGee, J. O'D.

PY - 1998

Y1 - 1998

N2 - Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. GIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six tone with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.

AB - Twenty per cent of cervical intraepithelial neoplasias-III (CIN-III) progress to invasive cancer. Human papillomavirus (HPV) infection alone does not determine progression. GIN-III lesions were collected from 161 women. Each tissue was microdissected into a maximum of 32 contiguous units and assayed at multiple microsatellite loci on chromosome 11q, a region frequently deleted in invasive cervical and other cancers. Eight of 108 informative cases (7%) had 11q23.3-q25 deletions; focally intra-lesional in six tone with focal loss of alternate alleles), and pan-lesional in two cases. Hence, 11q deletion can occur early in cervical neoplasia, and possibly predisposes to invasion.

M3 - Article

SN - 0950-9232

VL - 16

SP - 2557

EP - 2564

JO - Oncogene

JF - Oncogene

IS - 19

ER -

Allelic deletion at 11q23.3-q25 is an early event in cervical neoplasia

Abstract

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