Allopurinol use is associated with greater functional gains in older rehabilitation patients

Louise A. Beveridge, Lynn Ramage, Marion E. T. McMurdo, Jacob George, Miles D. Witham

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    Introduction: the xanthine oxidase system produces reactive oxidative species and its inhibition by allopurinol has been shown to have beneficial effects on cardiovascular function. Oxidative stress has also been implicated in the development of sarcopenia. Allopurinol, a xanthine oxidase inhibitor, both reduces oxidative stress and acts as a potential oxygen-sparing agent. We examined the association between allopurinol use and functional outcomes after rehabilitation in a cohort of older people.

    Methods: analysis of routinely collected clinical data from a single rehabilitation unit. Data were prospectively collected on all admissions to the Dundee Medicine for the Elderly rehabilitation unit between 1 January 1999 and 31 December 2008. Multivariate analyses were performed to examine the difference between the 20-point Barthel score on admission and discharge, adjusting for age, sex, admission Barthel score, anti-platelet use and comorbid disease.

    Results: a total of 3,593 patients were included in the analysis and 3% of patients were taking allopurinol on discharge (n = 102). Improvement in Barthel scores was greater in the allopurinol group than the non-allopurinol group (4.7 versus 3.6 points, mean difference 1.1, 95% CI: 0.4-1.8, P = 0.002). When adjusted for age, sex, admission Barthel, presenting disease and number of drugs on discharge, improvement in the Barthel score was still greater in the allopurinol group (4.8 versus 3.8 points, mean difference 0.94, 95% CI: 0.3 to 1.6, P = 0.006).

    Conclusions: this retrospective observational study suggests that allopurinol use is associated with a greater degree of improvement in function as measured by the Barthel score during rehabilitation in an older inpatient population. Prospective randomised controlled trials are required to further investigate this finding.

    Original languageEnglish
    Pages (from-to)400-404
    Number of pages5
    JournalAge and Ageing
    Volume42
    Issue number3
    DOIs
    Publication statusPublished - 2013

    Keywords

    • ENDOTHELIAL FUNCTION
    • allopurinol
    • PEOPLE
    • OXIDATIVE STRESS
    • older people
    • oxidative stress
    • rehabilitation

    Cite this

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    title = "Allopurinol use is associated with greater functional gains in older rehabilitation patients",
    abstract = "Introduction: the xanthine oxidase system produces reactive oxidative species and its inhibition by allopurinol has been shown to have beneficial effects on cardiovascular function. Oxidative stress has also been implicated in the development of sarcopenia. Allopurinol, a xanthine oxidase inhibitor, both reduces oxidative stress and acts as a potential oxygen-sparing agent. We examined the association between allopurinol use and functional outcomes after rehabilitation in a cohort of older people.Methods: analysis of routinely collected clinical data from a single rehabilitation unit. Data were prospectively collected on all admissions to the Dundee Medicine for the Elderly rehabilitation unit between 1 January 1999 and 31 December 2008. Multivariate analyses were performed to examine the difference between the 20-point Barthel score on admission and discharge, adjusting for age, sex, admission Barthel score, anti-platelet use and comorbid disease.Results: a total of 3,593 patients were included in the analysis and 3{\%} of patients were taking allopurinol on discharge (n = 102). Improvement in Barthel scores was greater in the allopurinol group than the non-allopurinol group (4.7 versus 3.6 points, mean difference 1.1, 95{\%} CI: 0.4-1.8, P = 0.002). When adjusted for age, sex, admission Barthel, presenting disease and number of drugs on discharge, improvement in the Barthel score was still greater in the allopurinol group (4.8 versus 3.8 points, mean difference 0.94, 95{\%} CI: 0.3 to 1.6, P = 0.006).Conclusions: this retrospective observational study suggests that allopurinol use is associated with a greater degree of improvement in function as measured by the Barthel score during rehabilitation in an older inpatient population. Prospective randomised controlled trials are required to further investigate this finding.",
    keywords = "ENDOTHELIAL FUNCTION, allopurinol, PEOPLE, OXIDATIVE STRESS, older people, oxidative stress, rehabilitation",
    author = "Beveridge, {Louise A.} and Lynn Ramage and McMurdo, {Marion E. T.} and Jacob George and Witham, {Miles D.}",
    year = "2013",
    doi = "10.1093/ageing/aft046",
    language = "English",
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    pages = "400--404",
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    Allopurinol use is associated with greater functional gains in older rehabilitation patients. / Beveridge, Louise A.; Ramage, Lynn; McMurdo, Marion E. T.; George, Jacob; Witham, Miles D.

    In: Age and Ageing, Vol. 42, No. 3, 2013, p. 400-404.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Allopurinol use is associated with greater functional gains in older rehabilitation patients

    AU - Beveridge, Louise A.

    AU - Ramage, Lynn

    AU - McMurdo, Marion E. T.

    AU - George, Jacob

    AU - Witham, Miles D.

    PY - 2013

    Y1 - 2013

    N2 - Introduction: the xanthine oxidase system produces reactive oxidative species and its inhibition by allopurinol has been shown to have beneficial effects on cardiovascular function. Oxidative stress has also been implicated in the development of sarcopenia. Allopurinol, a xanthine oxidase inhibitor, both reduces oxidative stress and acts as a potential oxygen-sparing agent. We examined the association between allopurinol use and functional outcomes after rehabilitation in a cohort of older people.Methods: analysis of routinely collected clinical data from a single rehabilitation unit. Data were prospectively collected on all admissions to the Dundee Medicine for the Elderly rehabilitation unit between 1 January 1999 and 31 December 2008. Multivariate analyses were performed to examine the difference between the 20-point Barthel score on admission and discharge, adjusting for age, sex, admission Barthel score, anti-platelet use and comorbid disease.Results: a total of 3,593 patients were included in the analysis and 3% of patients were taking allopurinol on discharge (n = 102). Improvement in Barthel scores was greater in the allopurinol group than the non-allopurinol group (4.7 versus 3.6 points, mean difference 1.1, 95% CI: 0.4-1.8, P = 0.002). When adjusted for age, sex, admission Barthel, presenting disease and number of drugs on discharge, improvement in the Barthel score was still greater in the allopurinol group (4.8 versus 3.8 points, mean difference 0.94, 95% CI: 0.3 to 1.6, P = 0.006).Conclusions: this retrospective observational study suggests that allopurinol use is associated with a greater degree of improvement in function as measured by the Barthel score during rehabilitation in an older inpatient population. Prospective randomised controlled trials are required to further investigate this finding.

    AB - Introduction: the xanthine oxidase system produces reactive oxidative species and its inhibition by allopurinol has been shown to have beneficial effects on cardiovascular function. Oxidative stress has also been implicated in the development of sarcopenia. Allopurinol, a xanthine oxidase inhibitor, both reduces oxidative stress and acts as a potential oxygen-sparing agent. We examined the association between allopurinol use and functional outcomes after rehabilitation in a cohort of older people.Methods: analysis of routinely collected clinical data from a single rehabilitation unit. Data were prospectively collected on all admissions to the Dundee Medicine for the Elderly rehabilitation unit between 1 January 1999 and 31 December 2008. Multivariate analyses were performed to examine the difference between the 20-point Barthel score on admission and discharge, adjusting for age, sex, admission Barthel score, anti-platelet use and comorbid disease.Results: a total of 3,593 patients were included in the analysis and 3% of patients were taking allopurinol on discharge (n = 102). Improvement in Barthel scores was greater in the allopurinol group than the non-allopurinol group (4.7 versus 3.6 points, mean difference 1.1, 95% CI: 0.4-1.8, P = 0.002). When adjusted for age, sex, admission Barthel, presenting disease and number of drugs on discharge, improvement in the Barthel score was still greater in the allopurinol group (4.8 versus 3.8 points, mean difference 0.94, 95% CI: 0.3 to 1.6, P = 0.006).Conclusions: this retrospective observational study suggests that allopurinol use is associated with a greater degree of improvement in function as measured by the Barthel score during rehabilitation in an older inpatient population. Prospective randomised controlled trials are required to further investigate this finding.

    KW - ENDOTHELIAL FUNCTION

    KW - allopurinol

    KW - PEOPLE

    KW - OXIDATIVE STRESS

    KW - older people

    KW - oxidative stress

    KW - rehabilitation

    U2 - 10.1093/ageing/aft046

    DO - 10.1093/ageing/aft046

    M3 - Article

    C2 - 23542724

    VL - 42

    SP - 400

    EP - 404

    JO - Age and Ageing

    JF - Age and Ageing

    SN - 0002-0729

    IS - 3

    ER -