Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

Sarah C Cobbe, Gillian C Scobie, Elizabeth Pohler, John D Hayes, Neil M Kernohan, John F Dillon

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Oesophageal cancer associated with the premalignant condition Barrett's oesophagus has increased in incidence over the last few years. Phase II detoxifying enzymes, including glutathione S-transferases (GSTs) protect the mucosa from carcinogens, which can cause oxidative damage to cells. Therefore, a reduction in these anti-oxidant enzymes can increase the risk of carcinogenesis. The aim of this study was to compare the extent of GST expression in normal oesophageal tissue, Barrett's oesophagus and oesophageal adenocarcinoma.
    Original languageEnglish
    Pages (from-to)41-47
    Number of pages7
    JournalEuropean Journal of Gastroenterology & Hepatology
    Volume15
    Issue number1
    Publication statusPublished - 2003

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