Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

Sarah C Cobbe; Gillian C Scobie; Elizabeth Pohler; John D Hayes; Neil M Kernohan; John F Dillon

Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

Sarah C Cobbe, Gillian C Scobie, Elizabeth Pohler, John D Hayes, Neil M Kernohan, John F Dillon

Research output: Contribution to journal › Article › peer-review

Abstract

Oesophageal cancer associated with the premalignant condition Barrett's oesophagus has increased in incidence over the last few years. Phase II detoxifying enzymes, including glutathione S-transferases (GSTs) protect the mucosa from carcinogens, which can cause oxidative damage to cells. Therefore, a reduction in these anti-oxidant enzymes can increase the risk of carcinogenesis. The aim of this study was to compare the extent of GST expression in normal oesophageal tissue, Barrett's oesophagus and oesophageal adenocarcinoma.

Original language	English
Pages (from-to)	41-47
Number of pages	7
Journal	European Journal of Gastroenterology & Hepatology
Volume	15
Issue number	1
Publication status	Published - 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

http://journals.lww.com/eurojgh/pages/default.aspx

Cite this

@article{14cd785f3dae4ff8b455c183756c3c9e,

title = "Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium",

abstract = "Oesophageal cancer associated with the premalignant condition Barrett's oesophagus has increased in incidence over the last few years. Phase II detoxifying enzymes, including glutathione S-transferases (GSTs) protect the mucosa from carcinogens, which can cause oxidative damage to cells. Therefore, a reduction in these anti-oxidant enzymes can increase the risk of carcinogenesis. The aim of this study was to compare the extent of GST expression in normal oesophageal tissue, Barrett's oesophagus and oesophageal adenocarcinoma.",

author = "Cobbe, {Sarah C} and Scobie, {Gillian C} and Elizabeth Pohler and Hayes, {John D} and Kernohan, {Neil M} and Dillon, {John F}",

year = "2003",

language = "English",

volume = "15",

pages = "41--47",

journal = "European Journal of Gastroenterology & Hepatology",

issn = "0954-691X",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

AU - Cobbe, Sarah C

AU - Scobie, Gillian C

AU - Pohler, Elizabeth

AU - Hayes, John D

AU - Kernohan, Neil M

AU - Dillon, John F

PY - 2003

Y1 - 2003

N2 - Oesophageal cancer associated with the premalignant condition Barrett's oesophagus has increased in incidence over the last few years. Phase II detoxifying enzymes, including glutathione S-transferases (GSTs) protect the mucosa from carcinogens, which can cause oxidative damage to cells. Therefore, a reduction in these anti-oxidant enzymes can increase the risk of carcinogenesis. The aim of this study was to compare the extent of GST expression in normal oesophageal tissue, Barrett's oesophagus and oesophageal adenocarcinoma.

AB - Oesophageal cancer associated with the premalignant condition Barrett's oesophagus has increased in incidence over the last few years. Phase II detoxifying enzymes, including glutathione S-transferases (GSTs) protect the mucosa from carcinogens, which can cause oxidative damage to cells. Therefore, a reduction in these anti-oxidant enzymes can increase the risk of carcinogenesis. The aim of this study was to compare the extent of GST expression in normal oesophageal tissue, Barrett's oesophagus and oesophageal adenocarcinoma.

M3 - Article

C2 - 12544693

SN - 0954-691X

VL - 15

SP - 41

EP - 47

JO - European Journal of Gastroenterology & Hepatology

JF - European Journal of Gastroenterology & Hepatology

IS - 1

ER -

Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this