Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

TY - JOUR

T1 - Alteration of glutathione S-transferase levels in Barrett's metaplasia compared to normal oesophageal epithelium

AU - Cobbe, Sarah C

AU - Scobie, Gillian C

AU - Pohler, Elizabeth

AU - Hayes, John D

AU - Kernohan, Neil M

AU - Dillon, John F

N1 - Copyright 2002 Lippincott Williams & Wilkins

PY - 2003

Y1 - 2003

N2 - Oesophageal cancer associated with the premalignant condition Barrett's oesophagus has increased in incidence over the last few years. Phase II detoxifying enzymes, including glutathione S-transferases (GSTs) protect the mucosa from carcinogens, which can cause oxidative damage to cells. Therefore, a reduction in these anti-oxidant enzymes can increase the risk of carcinogenesis. The aim of this study was to compare the extent of GST expression in normal oesophageal tissue, Barrett's oesophagus and oesophageal adenocarcinoma.

AB - Oesophageal cancer associated with the premalignant condition Barrett's oesophagus has increased in incidence over the last few years. Phase II detoxifying enzymes, including glutathione S-transferases (GSTs) protect the mucosa from carcinogens, which can cause oxidative damage to cells. Therefore, a reduction in these anti-oxidant enzymes can increase the risk of carcinogenesis. The aim of this study was to compare the extent of GST expression in normal oesophageal tissue, Barrett's oesophagus and oesophageal adenocarcinoma.

M3 - Article

C2 - 12544693

SN - 0954-691X

VL - 15

SP - 41

EP - 47

JO - European Journal of Gastroenterology & Hepatology

JF - European Journal of Gastroenterology & Hepatology

IS - 1

ER -