Alteration of the growth-rate-dependent regulation of Escherichia coli tyrT expression by promoter mutations

Andrew A. Travers, Angus I. Lamond, John R. Weeks

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The growth-rate regulation of transcription of the Escherichia coli tyrT gene depends on sequences in at least two distinct regions of the promoter, the upstream element required for optimal activity and the discriminator adjacent to the transcription start-point. Since mutations in the discriminator also alter the response of the promoter to amino acid starvation, we conclude that growth rate and amino acid control mechanisms share a common target molecule, probably RNA polymerase.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalJournal of Molecular Biology
Volume189
Issue number1
DOIs
Publication statusPublished - 5 May 1986

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