Alteration of the growth-rate-dependent regulation of Escherichia coli tyrT expression by promoter mutations

Andrew A. Travers, Angus I. Lamond, John R. Weeks

    Research output: Contribution to journalArticlepeer-review

    23 Citations (Scopus)

    Abstract

    The growth-rate regulation of transcription of the Escherichia coli tyrT gene depends on sequences in at least two distinct regions of the promoter, the upstream element required for optimal activity and the discriminator adjacent to the transcription start-point. Since mutations in the discriminator also alter the response of the promoter to amino acid starvation, we conclude that growth rate and amino acid control mechanisms share a common target molecule, probably RNA polymerase.

    Original languageEnglish
    Pages (from-to)251-255
    Number of pages5
    JournalJournal of Molecular Biology
    Volume189
    Issue number1
    DOIs
    Publication statusPublished - 5 May 1986

    ASJC Scopus subject areas

    • Structural Biology
    • Molecular Biology

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