Abstract
The growth-rate regulation of transcription of the Escherichia coli tyrT gene depends on sequences in at least two distinct regions of the promoter, the upstream element required for optimal activity and the discriminator adjacent to the transcription start-point. Since mutations in the discriminator also alter the response of the promoter to amino acid starvation, we conclude that growth rate and amino acid control mechanisms share a common target molecule, probably RNA polymerase.
Original language | English |
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Pages (from-to) | 251-255 |
Number of pages | 5 |
Journal | Journal of Molecular Biology |
Volume | 189 |
Issue number | 1 |
DOIs | |
Publication status | Published - 5 May 1986 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology