Alteration of the growth-rate-dependent regulation of Escherichia coli tyrT expression by promoter mutations

TY - JOUR

T1 - Alteration of the growth-rate-dependent regulation of Escherichia coli tyrT expression by promoter mutations

AU - Travers, Andrew A.

AU - Lamond, Angus I.

AU - Weeks, John R.

PY - 1986/5/5

Y1 - 1986/5/5

N2 - The growth-rate regulation of transcription of the Escherichia coli tyrT gene depends on sequences in at least two distinct regions of the promoter, the upstream element required for optimal activity and the discriminator adjacent to the transcription start-point. Since mutations in the discriminator also alter the response of the promoter to amino acid starvation, we conclude that growth rate and amino acid control mechanisms share a common target molecule, probably RNA polymerase.

AB - The growth-rate regulation of transcription of the Escherichia coli tyrT gene depends on sequences in at least two distinct regions of the promoter, the upstream element required for optimal activity and the discriminator adjacent to the transcription start-point. Since mutations in the discriminator also alter the response of the promoter to amino acid starvation, we conclude that growth rate and amino acid control mechanisms share a common target molecule, probably RNA polymerase.

UR - https://www.scopus.com/pages/publications/0023042241

U2 - 10.1016/0022-2836(86)90397-9

DO - 10.1016/0022-2836(86)90397-9

M3 - Article

C2 - 3537307

AN - SCOPUS:0023042241

SN - 0022-2836

VL - 189

SP - 251

EP - 255

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 1

ER -