Projects per year
Abstract
Flowering time is controlled by precision in gene regulation mediated by different pathways. Two Arabidopsis thallium, components of the autonomous flowering pathway, FCA and FPA, function as genetically independent frons-acting regulators of alternative cleavage and polyadenylation. FCA and FPA directly associate with chromatin at the locus encoding the floral repressor FLC, but appear to control FLC transcription by mediating alternative polyadenylation of embedded non-coding antisense RNAs. These findings prompt the re-examination of how other factors control FLC expression, as it is formally possible that they function primarily to control alternative processing of antisense RNAs. As co-expressed sense and antisense gene pairs are wide spread in eukaryotes, alternative processing of antisense RNAs may represent a significant form of gene regulation.
Original language | English |
---|---|
Pages (from-to) | 1077-1081 |
Number of pages | 5 |
Journal | Biochemical Society Transactions |
Volume | 38 |
DOIs | |
Publication status | Published - Aug 2010 |
Keywords
- alternative polyadenylation
- antisense RNA
- chromatin
- flowering time control
- spen
- ARABIDOPSIS-THALIANA
- AUTONOMOUS PATHWAY
- LOCUS-C
- BINDING PROTEIN
- FLORAL TRANSITION
- REPEAT PROTEIN
- GENE
- FCA
- TRANSCRIPTION
- YEAST
Fingerprint
Dive into the research topics of 'Alternative polyadenylation of antisense RNAs and flowering time control'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Aref#d: 21678. Elucidating Mechanisms and Roles of Alternative Polyadenylation
Barton, G. (Investigator) & Simpson, G. (Investigator)
1/12/09 → 16/05/13
Project: Research