Alternative splicing of the mRNA encoding the α subunits of the Go GTP-binding protein during brain development and in neuronal cell lines

David A. Horn, David S. Latchman

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The RNA encoding the α subunit of the Go GTP-binding protein is alternatively spliced in some tissues to produce mRNAs encoding two distinct forms of the protein which differ at the carboxyl terminus. This alternative splicing process is observed at all stages during development of the rat brain and heart and in some but not all neuronal cell lines. These effects are discussed both in terms of the regulation of the alternative splicing event and the functional role(s) of the two forms of the protein which it produces.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Volume155
Issue number1
DOIs
Publication statusPublished - 28 May 1993

Keywords

  • Alternative splicing
  • G-protein
  • G
  • α Subunit mRNA

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