Alzheimer's disease risk factor complement receptor 1 is associated with depression

Gillian Hamilton; Kathryn L. Evans; Donald J. MacIntyre; Ian J. Deary; Anna Dominiczak; Blair H. Smith; Andrew D. Morris; David J. Porteous; Pippa A. Thomson

doi:10.1016/j.neulet.2011.12.059

Alzheimer's disease risk factor complement receptor 1 is associated with depression

Gillian Hamilton, Kathryn L. Evans, Donald J. MacIntyre, Ian J. Deary, Anna Dominiczak, Blair H. Smith, Andrew D. Morris, David J. Porteous, Pippa A. Thomson

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18 Citations (Scopus)

Abstract

Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	6-9
Number of pages	4
Journal	Neuroscience Letters
Volume	510
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2011.12.059
Publication status	Published - 2012

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10.1016/j.neulet.2011.12.059

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abstract = "Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study. (C) 2012 Elsevier Ireland Ltd. All rights reserved.",

author = "Gillian Hamilton and Evans, {Kathryn L.} and MacIntyre, {Donald J.} and Deary, {Ian J.} and Anna Dominiczak and Smith, {Blair H.} and Morris, {Andrew D.} and Porteous, {David J.} and Thomson, {Pippa A.}",

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AU - Evans, Kathryn L.

AU - MacIntyre, Donald J.

AU - Deary, Ian J.

AU - Dominiczak, Anna

AU - Smith, Blair H.

AU - Morris, Andrew D.

AU - Porteous, David J.

AU - Thomson, Pippa A.

PY - 2012

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AB - Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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JO - Neuroscience Letters

JF - Neuroscience Letters

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Alzheimer's disease risk factor complement receptor 1 is associated with depression

Abstract

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