Alzheimer's disease risk factor complement receptor 1 is associated with depression

Gillian Hamilton, Kathryn L. Evans, Donald J. MacIntyre, Ian J. Deary, Anna Dominiczak, Blair H. Smith, Andrew D. Morris, David J. Porteous, Pippa A. Thomson

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    Abstract

    Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)6-9
    Number of pages4
    JournalNeuroscience Letters
    Volume510
    Issue number1
    DOIs
    Publication statusPublished - 2012

    Cite this

    Hamilton, G., Evans, K. L., MacIntyre, D. J., Deary, I. J., Dominiczak, A., Smith, B. H., Morris, A. D., Porteous, D. J., & Thomson, P. A. (2012). Alzheimer's disease risk factor complement receptor 1 is associated with depression. Neuroscience Letters, 510(1), 6-9. https://doi.org/10.1016/j.neulet.2011.12.059