Amide bond replacements: incorporation of a 2,5,5-trisubstituted imidazoline into dipeptides and into a CCK-4 derivative

Ian Gilbert, David C. Rees, Reginald S. Richardson

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    Abstract

    Synthetic methodology for the introduction of a 2,5,5-trisubstituted imidazoline ring as an amide replacement into dipeptide derivatives of Phe, Trp, Lys (N-epsilon-CBZ) and Nle is described. This replacement is also incorporated into the Trp-Nle bond of the tetrapeptide CCK-4 derivative Trp-Nle-Asp-Phe-NH2 and the pentagastrin derivative Gly-Trp-Nle-Asp-Phe-NH2.

    Original languageEnglish
    Pages (from-to)2277-2280
    Number of pages4
    JournalTetrahedron Letters
    Volume32
    Issue number20
    DOIs
    Publication statusPublished - 13 May 1991

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