Amino-acid substitution in the α1β1 intersubunit contact of haemoglobin-camden β131 (H9) gln→glu

Patricia T. Wade  Cohen; A. Yates; A. J. Bellingham; E. R. Huehns

doi:10.1038/243467a0

Amino-acid substitution in the α¹β¹ intersubunit contact of haemoglobin-camden β131 (H9) gln→glu

Patricia T. Wade Cohen, A. Yates, A. J. Bellingham, E. R. Huehns

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Abstract

THE structures of more than 100 variant human haemoglobins have been determined and in many cases it has been possible to relate the position of the individual amino-acid substitution to the stability and function of the molecule^1,2. Here we describe the amino-acid replacement, structural alterations and oxygenation properties of a variant, haemoglobin-Camden, which has a substitution in the α¹β¹ intersubunit contact of the haemoglobin molecule.

Original language	English
Pages (from-to)	467-468
Number of pages	2
Journal	Nature
Volume	243
Issue number	5408
DOIs	https://doi.org/10.1038/243467a0
Publication status	Published - 1 Dec 1973

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abstract = "THE structures of more than 100 variant human haemoglobins have been determined and in many cases it has been possible to relate the position of the individual amino-acid substitution to the stability and function of the molecule1,2. Here we describe the amino-acid replacement, structural alterations and oxygenation properties of a variant, haemoglobin-Camden, which has a substitution in the α1β1 intersubunit contact of the haemoglobin molecule.",

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AU - Huehns, E. R.

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N2 - THE structures of more than 100 variant human haemoglobins have been determined and in many cases it has been possible to relate the position of the individual amino-acid substitution to the stability and function of the molecule1,2. Here we describe the amino-acid replacement, structural alterations and oxygenation properties of a variant, haemoglobin-Camden, which has a substitution in the α1β1 intersubunit contact of the haemoglobin molecule.

AB - THE structures of more than 100 variant human haemoglobins have been determined and in many cases it has been possible to relate the position of the individual amino-acid substitution to the stability and function of the molecule1,2. Here we describe the amino-acid replacement, structural alterations and oxygenation properties of a variant, haemoglobin-Camden, which has a substitution in the α1β1 intersubunit contact of the haemoglobin molecule.

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Amino-acid substitution in the α¹β¹ intersubunit contact of haemoglobin-camden β131 (H9) gln→glu

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