Amino-acid substitution in the α1β1 intersubunit contact of haemoglobin-camden β131 (H9) gln→glu

Patricia T. Wade Cohen, A. Yates, A. J. Bellingham, E. R. Huehns

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    THE structures of more than 100 variant human haemoglobins have been determined and in many cases it has been possible to relate the position of the individual amino-acid substitution to the stability and function of the molecule1,2. Here we describe the amino-acid replacement, structural alterations and oxygenation properties of a variant, haemoglobin-Camden, which has a substitution in the α1β1 intersubunit contact of the haemoglobin molecule.

    Original languageEnglish
    Pages (from-to)467-468
    Number of pages2
    JournalNature
    Volume243
    Issue number5408
    DOIs
    Publication statusPublished - 1 Dec 1973

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