AMP-activated protein kinase

Grahame Hardie (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary


AMP-activated protein kinase (AMPK) is a member of the serine/threonine protein kinase family, which modify other proteins (target proteins) by attaching phosphate groups to the side chains of serine or threonine, thus modifying their function. The primary role of AMPK is to sense energy status by monitoring the cellular ratios of AMP:ATP and ADP:AMP. Once activated by energy stress, AMPK acts to restore homeostasis by switching off downstream processes consuming ATP (such as cell growth and proliferation) while switching on catabolic processes generating ATP (such as glucose uptake and mitochondrial biogenesis). AMPK is also involved in regulating whole-body energy balance and has been identified as a key target in treating disorders such as obesity and type 2 diabetes.

Original languageEnglish
Title of host publicationEncyclopedia of Molecular Pharmacology
EditorsStefan Offermanns, Walter Rosenthal
Place of PublicationSwitzerland
Number of pages7
ISBN (Print)9783540389217
Publication statusPublished - 7 Jan 2022


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