AMP-activated protein kinase

Grahame Hardie

doi:10.1007/978-3-030-57401-7_177

AMP-activated protein kinase

Grahame Hardie (Lead / Corresponding author)

Cell Signalling and Immunology

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

Abstract

AMP-activated protein kinase (AMPK) is a member of the serine/threonine protein kinase family, which modify other proteins (target proteins) by attaching phosphate groups to the side chains of serine or threonine, thus modifying their function. The primary role of AMPK is to sense energy status by monitoring the cellular ratios of AMP:ATP and ADP:AMP. Once activated by energy stress, AMPK acts to restore homeostasis by switching off downstream processes consuming ATP (such as cell growth and proliferation) while switching on catabolic processes generating ATP (such as glucose uptake and mitochondrial biogenesis). AMPK is also involved in regulating whole-body energy balance and has been identified as a key target in treating disorders such as obesity and type 2 diabetes.

Original language	English
Title of host publication	Encyclopedia of Molecular Pharmacology
Editors	Stefan Offermanns, Walter Rosenthal
Place of Publication	Switzerland
Publisher	Springer
Pages	90-96
Number of pages	7
Edition	3
ISBN (Print)	9783540389217
DOIs	https://doi.org/10.1007/978-3-030-57401-7_177
Publication status	Published - 7 Jan 2022

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10.1007/978-3-030-57401-7_177

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AMP-activated protein kinase

Abstract

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