AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

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    Abstract

    AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role may have been in the response to starvation. Recent work shows that the kinase is activated by increases not only in AMP, but also in ADP. Although best known for its effects on metabolism, AMPK has many other functions, including regulation of mitochondrial biogenesis and disposal, autophagy, cell polarity, and cell growth and proliferation. Both tumor cells and viruses establish mechanisms to down-regulate AMPK, allowing them to escape its restraining influences on growth.

    Original languageEnglish
    Pages (from-to)1895-1908
    Number of pages14
    JournalGenes & Development
    Volume25
    Issue number18
    DOIs
    Publication statusPublished - 15 Sep 2011

    Keywords

    • AMP-activated protein kinase
    • AMPK
    • metabolism
    • autophagy
    • cell polarity
    • cell proliferation
    • FATTY-ACID OXIDATION
    • HAPLOID INVASIVE GROWTH
    • TUMOR-SUPPRESSOR LKB1
    • HMG-COA REDUCTASE
    • SKELETAL-MUSCLE
    • SACCHAROMYCES-CEREVISIAE
    • C-ELEGANS
    • YEAST SNF1
    • DIRECT PHOSPHORYLATION
    • METABOLIC CHECKPOINT

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