AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System

Ian P. Salt, D. Grahame Hardie (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

73 Citations (Scopus)
122 Downloads (Pure)

Abstract

The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy charge is depleted. Over the last 2 decades, it has become apparent that AMPK regulates several other cellular functions and has specific roles in cardiovascular tissues, acting to regulate cardiac metabolism and contractile function, as well as promoting anticontractile, anti-inflammatory, and antiatherogenic actions in blood vessels. In this review, we discuss the role of AMPK in the cardiovascular system, including the molecular basis of mutations in AMPK that alter cardiac physiology and the proposed mechanisms by which AMPK regulates vascular function under physiological and pathophysiological conditions.

Original languageEnglish
Pages (from-to)1825-1841
Number of pages17
JournalCirculation Research
Volume120
Issue number11
Early online date25 May 2017
DOIs
Publication statusPublished - 26 May 2017

Keywords

  • AMP-activated protein kinase
  • Heart
  • Heart defects (congenital)
  • Metabolism
  • Vasculature

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