AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

D. Grahame Hardie

doi:10.1038/nrm2249

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

D. Grahame Hardie

Research output: Contribution to journal › Article › peer-review

1894 Citations (Scopus)

Abstract

The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP production and consumption in all eukaryotic cells. The kinases are heterotrimers that comprise a catalytic subunit and regulatory subunits that sense cellular energy levels. When energy status is compromised, the system activates catabolic pathways and switches off protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. Surprisingly, recent results indicate that the AMPK system is also important in functions that go beyond the regulation of energy homeostasis, such as the maintenance of cell polarity in epithelial cells.

Original language	English
Pages (from-to)	774-85
Number of pages	12
Journal	Nature Reviews Molecular Cell Biology
Volume	8
Issue number	10
DOIs	https://doi.org/10.1038/nrm2249
Publication status	Published - Oct 2007

Keywords

AMP-Activated Protein Kinases
Animals
Conserved Sequence
Energy Metabolism
Humans
Multienzyme Complexes
Protein-Serine-Threonine Kinases

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10.1038/nrm2249

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abstract = "The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP production and consumption in all eukaryotic cells. The kinases are heterotrimers that comprise a catalytic subunit and regulatory subunits that sense cellular energy levels. When energy status is compromised, the system activates catabolic pathways and switches off protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. Surprisingly, recent results indicate that the AMPK system is also important in functions that go beyond the regulation of energy homeostasis, such as the maintenance of cell polarity in epithelial cells.",

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KW - AMP-Activated Protein Kinases

KW - Animals

KW - Conserved Sequence

KW - Energy Metabolism

KW - Humans

KW - Multienzyme Complexes

KW - Protein-Serine-Threonine Kinases

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JO - Nature Reviews Molecular Cell Biology

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ER -

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

Abstract

Keywords

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