AMPK: a nutrient and energy sensor that maintains energy homeostasis

D. Grahame Hardie (Lead / Corresponding author), Fiona A. Ross, Simon A. Hawley

    Research output: Contribution to journalReview articlepeer-review

    3346 Citations (Scopus)
    414 Downloads (Pure)


    AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by falling energy status, it promotes ATP production by increasing the activity or expression of proteins involved in catabolism while conserving ATP by switching off biosynthetic pathways. AMPK also regulates metabolic energy balance at the whole-body level. For example, it mediates the effects of agents acting on the hypothalamus that promote feeding and entrains circadian rhythms of metabolism and feeding behaviour. Finally, recent studies reveal that AMPK conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability.
    Original languageEnglish
    Pages (from-to)251-262
    Number of pages12
    JournalNature Reviews Molecular Cell Biology
    Issue number4
    Publication statusPublished - 1 Apr 2012


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