AMPK and autophagy get connected

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    111 Citations (Scopus)

    Abstract

    The energy sensor AMP-activated protein kinase (AMPK), which is activated by ATP depletion or glucose starvation, was previously thought to activate autophagy entirely through its ability to inactivate mTOR complex-1. Two recent papers now provide evidence that it also mediates this by direct phosphorylation of the protein kinase that initiate autophagy, ULK1. Surprisingly, however, the two groups identified different sites on ULK1.

    Original languageEnglish
    Pages (from-to)634-635
    Number of pages2
    JournalEMBO Journal
    Volume30
    Issue number4
    DOIs
    Publication statusPublished - 16 Feb 2011

    Keywords

    • CELLULAR-ENERGY
    • GROWTH

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