AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B

Keyphrases

• Phosphorylation 100%
• AMP-activated Protein Kinase 100%
• Glucagon 100%
• Induced Activation 100%
• Cyclic AMP Signaling 100%
• Cyclic nucleotide Phosphodiesterase 100%
• PDE4B 100%
• Hepatocytes 60%
• Incubation 40%
• Cyclic Adenosine Monophosphate (cAMP) 40%
• Protein Kinase 20%
• Metformin 20%
• Protein Kinase Activity 20%
• Catalytic Subunit 20%
• Site-directed mutagenesis 20%
• Adenine nucleotides 20%
• Small Molecules 20%
• Biguanides 20%
• Adenylate Cyclase 20%
• Kinase Target 20%
• AMP-activated Protein Kinase Activator 20%
• Vmax 20%
• Cyclic AMP-dependent Protein Kinase 20%
• Direct Inhibitors 20%
• Glucagon Signaling Pathway 20%

Biochemistry, Genetics and Molecular Biology

• Cyclic Adenosine Monophosphate 100%
• AMP-activated Protein Kinase 100%
• Cyclic Nucleotide Phosphodiesterase 100%
• Glucagon 100%
• phosphorylation 100%
• Phosphodiesterase 50%
• Hepatocyte 50%
• Small Molecule 16%
• Enzyme Active Site 16%
• Adenylate Cyclase 16%
• Protein Kinases 16%
• Protein Kinase A 16%
• Adenosine Monophosphate 16%
• Site-Directed Mutagenesis 16%
• Adenine 16%
• Maximum Reaction Velocity 16%
• Nucleotide 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Hydroxymethylglutaryl Coenzyme A Reductase Kinase 100%
• Glucagon 100%
• Cyclic AMP 100%
• Cyclic Nucleotide Phosphodiesterase 100%
• Phosphodiesterase 60%
• Cyclic AMP Dependent Protein Kinase 20%
• Adenosine Phosphate 20%
• Protein Kinases 20%
• Metformin 20%
• Adenine Nucleotide 20%
• Site-Directed Mutagenesis 20%
• Adenylate Cyclase 20%
• Hydroxymethylglutaryl Coenzyme A Reductase Kinase Activator 20%
• Biguanide Derivative 20%