AMPK as a direct sensor of long-chain fatty acyl–CoA esters

D. Grahame Hardie

doi:10.1038/s42255-020-0249-y

AMPK as a direct sensor of long-chain fatty acyl–CoA esters

D. Grahame Hardie (Lead / Corresponding author)

Cell Signalling and Immunology

Research output: Contribution to journal › Comment/debate › peer-review

8 Citations (Scopus)

113 Downloads (Pure)

Abstract

AMPK is a crucial sensor of the cellular energetic state and is also activated during glucose starvation. A new study reports that AMP-activated protein kinase (AMPK) is activated by interaction with long-chain fatty acyl–CoA esters, which appear to be the long-sought endogenous AMPK ligands that bind the allosteric drug and metabolite (ADaM) site.

Original language	English
Pages (from-to)	799-800
Number of pages	2
Journal	Nature Metabolism
Volume	2
Issue number	9
DOIs	https://doi.org/10.1038/s42255-020-0249-y
Publication status	Published - 27 Jul 2020

Keywords

Kinases
Metabolism
Nutrient signalling

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Physiology (medical)
Internal Medicine
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s42255-020-0249-y

Author Accepted ManuscriptAccepted author manuscript, 149 KB

Cite this

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abstract = "AMPK is a crucial sensor of the cellular energetic state and is also activated during glucose starvation. A new study reports that AMP-activated protein kinase (AMPK) is activated by interaction with long-chain fatty acyl–CoA esters, which appear to be the long-sought endogenous AMPK ligands that bind the allosteric drug and metabolite (ADaM) site.",

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AB - AMPK is a crucial sensor of the cellular energetic state and is also activated during glucose starvation. A new study reports that AMP-activated protein kinase (AMPK) is activated by interaction with long-chain fatty acyl–CoA esters, which appear to be the long-sought endogenous AMPK ligands that bind the allosteric drug and metabolite (ADaM) site.

KW - Kinases

KW - Metabolism

KW - Nutrient signalling

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DO - 10.1038/s42255-020-0249-y

M3 - Comment/debate

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JO - Nature Metabolism

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ER -

AMPK as a direct sensor of long-chain fatty acyl–CoA esters

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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