AMPK: mediating the metabolic effects of salicylate-based drugs?

Gregory R. Steinberg (Lead / Corresponding author), Madhumita Dandapani, D. Grahame Hardie (Lead / Corresponding author)

    Research output: Contribution to journalReview article

    44 Citations (Scopus)

    Abstract

    Salicylates are among the oldest medicinal compounds known to humans, and have been used to reduce fever, pain, and inflammation. The major oral salicylates are aspirin and salsalate, both of which are rapidly metabolized to salicylate in vivo. Owing to its acetyl group, aspirin irreversibly inhibits cyclo-oxygenases and thus blocks platelet aggregation, whereas salsalate has been used for treatment of inflammatory diseases such as rheumatoid arthritis. Recently, beneficial effects of salicylates in type 2 diabetes and cancer have been proposed. This has led to renewed interest in understanding how these simple molecules have such diverse and multifaceted effects. Here we discuss the idea that AMP-activated protein kinase (AMPK) might mediate some effects of salicylate-based drugs, particularly by modulating cellular metabolism.

    Original languageEnglish
    Pages (from-to)481-487
    Number of pages7
    JournalTrends in Endocrinology and Metabolism
    Volume24
    Issue number10
    Early online date19 Jul 2013
    DOIs
    Publication statusPublished - Oct 2013

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