AMPK promotes lysosomal and mitochondrial biogenesis via folliculin: FNIP1

Jordana B. Freemantle, D. Grahame Hardie (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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Abstract

The AMP-activated protein kinase (AMPK) is known to maintain the integrity of cellular mitochondrial networks by (i) promoting fission, (ii) inhibiting fusion, (iii) promoting recycling of damaged components via mitophagy, (iv) enhancing lysosomal biogenesis to support mitophagy, and (v) promoting biogenesis of new mitochondrial components. While the AMPK targets underlying the first three of these effects are known, a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1 (FNIP1) by AMPK may be involved in the remaining two.

Original languageEnglish
Article numberload027
Number of pages4
JournalLife Metabolism
Volume2
Issue number5
Early online date22 Jun 2023
DOIs
Publication statusPublished - Oct 2023

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