AMPK promotes lysosomal and mitochondrial biogenesis via folliculin: FNIP1

Jordana B. Freemantle; D. Grahame Hardie

doi:10.1093/lifemeta/load027

AMPK promotes lysosomal and mitochondrial biogenesis via folliculin: FNIP1

Jordana B. Freemantle, D. Grahame Hardie (Lead / Corresponding author)

Cell Signalling and Immunology

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3 Citations (Scopus)

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Abstract

The AMP-activated protein kinase (AMPK) is known to maintain the integrity of cellular mitochondrial networks by (i) promoting fission, (ii) inhibiting fusion, (iii) promoting recycling of damaged components via mitophagy, (iv) enhancing lysosomal biogenesis to support mitophagy, and (v) promoting biogenesis of new mitochondrial components. While the AMPK targets underlying the first three of these effects are known, a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1 (FNIP1) by AMPK may be involved in the remaining two.

Original language	English
Article number	load027
Number of pages	4
Journal	Life Metabolism
Volume	2
Issue number	5
Early online date	22 Jun 2023
DOIs	https://doi.org/10.1093/lifemeta/load027
Publication status	Published - Oct 2023

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10.1093/lifemeta/load027Licence: CC BY

Final Published VersionFinal published version, 331 KBLicence: CC BY

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title = "AMPK promotes lysosomal and mitochondrial biogenesis via folliculin: FNIP1",

abstract = "The AMP-activated protein kinase (AMPK) is known to maintain the integrity of cellular mitochondrial networks by (i) promoting fission, (ii) inhibiting fusion, (iii) promoting recycling of damaged components via mitophagy, (iv) enhancing lysosomal biogenesis to support mitophagy, and (v) promoting biogenesis of new mitochondrial components. While the AMPK targets underlying the first three of these effects are known, a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1 (FNIP1) by AMPK may be involved in the remaining two.",

author = "Freemantle, {Jordana B.} and Hardie, {D. Grahame}",

note = "Funding Information: This work was supported by an Investigator Award from the Wellcome Trust (204766/Z/16/Z). Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.",

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Y1 - 2023/10

N2 - The AMP-activated protein kinase (AMPK) is known to maintain the integrity of cellular mitochondrial networks by (i) promoting fission, (ii) inhibiting fusion, (iii) promoting recycling of damaged components via mitophagy, (iv) enhancing lysosomal biogenesis to support mitophagy, and (v) promoting biogenesis of new mitochondrial components. While the AMPK targets underlying the first three of these effects are known, a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1 (FNIP1) by AMPK may be involved in the remaining two.

AB - The AMP-activated protein kinase (AMPK) is known to maintain the integrity of cellular mitochondrial networks by (i) promoting fission, (ii) inhibiting fusion, (iii) promoting recycling of damaged components via mitophagy, (iv) enhancing lysosomal biogenesis to support mitophagy, and (v) promoting biogenesis of new mitochondrial components. While the AMPK targets underlying the first three of these effects are known, a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1 (FNIP1) by AMPK may be involved in the remaining two.

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JO - Life Metabolism

JF - Life Metabolism

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ER -

AMPK promotes lysosomal and mitochondrial biogenesis via folliculin: FNIP1

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Role of AMPK in Nutrient Sensing and in Cancer (Investigator Award Renewal)

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AMPK promotes lysosomal and mitochondrial biogenesis via folliculin: FNIP1

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Role of AMPK in Nutrient Sensing and in Cancer (Investigator Award Renewal)

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