AMPK: regulating energy balance at the cellular and whole body levels

D. Grahame Hardie; Michael L. J. Ashford

doi:10.1152/physiol.00050.2013

AMPK: regulating energy balance at the cellular and whole body levels

D. Grahame Hardie, Michael L. J. Ashford

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231 Citations (Scopus)

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Abstract

AMP-activated protein kinase appears to have evolved in single-celled eukaryotes as an adenine nucleotide sensor that maintains energy homeostasis at the cellular level. However, during evolution of more complex multicellular organisms, the system has adapted to interact with hormones so that it also plays a key role in balancing energy intake and expenditure at the whole body level.

Original language	English
Pages (from-to)	99-107
Number of pages	9
Journal	Physiology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1152/physiol.00050.2013
Publication status	Published - Mar 2014

ASJC Scopus subject areas

Physiology
General Medicine

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10.1152/physiol.00050.2013Licence: CC BY

Final published version
©2014 Int. Union Physiol. Sci./Am. Physiol. Soc. Licensed under Creative Commons Attribution CC-BY 3.0: the American Physiological Society.
Final published version, 498 KBLicence: CC BY

Cite this

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abstract = "AMP-activated protein kinase appears to have evolved in single-celled eukaryotes as an adenine nucleotide sensor that maintains energy homeostasis at the cellular level. However, during evolution of more complex multicellular organisms, the system has adapted to interact with hormones so that it also plays a key role in balancing energy intake and expenditure at the whole body level.",

author = "Hardie, {D. Grahame} and Ashford, {Michael L. J.}",

note = "Recent studies in the D. G. Hardie laboratory have been supported by a Senior Investigator Award from the Wellcome Trust, and a Programme Grant from Cancer Research-UK, whereas M. L. J. Ashford has been supported by grants from the Medical Research Council and Diabetes UK.",

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AMPK: regulating energy balance at the cellular and whole body levels

Abstract

ASJC Scopus subject areas

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Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity

Non-canonical Pathways for Regulation of AMPK (Senior Investigator Award)

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AMPK: regulating energy balance at the cellular and whole body levels

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Targeting the Aspartic Protease BACE1 for Inhibition in Order to Increase Hypothalamic Leptin Sensitivity and Reverse Obesity

Non-canonical Pathways for Regulation of AMPK (Senior Investigator Award)

Cite this