TY - JOUR
T1 - Amplified biochemical oscillations in cellular systems
AU - McKane, A. J.
AU - Nagy, J. D.
AU - Newman, T. J.
AU - Stefanini, M. O.
PY - 2007/7
Y1 - 2007/7
N2 - We describe a mechanism for pronounced biochemical oscillations, relevant to microscopic systems, such as the intracellular environment. This mechanism operates for reaction schemes which, when modeled using deterministic rate equations, fail to exhibit oscillations for any values of rate constants. The mechanism relies on amplification of the underlying stochasticity of reaction kinetics within a narrow window of frequencies. This amplification means that fluctuations have a dominant effect, even though the number of molecules in the system is relatively large. The mechanism is quantitatively studied within simple models of self-regulatory gene expression, and glycolytic oscillations.
AB - We describe a mechanism for pronounced biochemical oscillations, relevant to microscopic systems, such as the intracellular environment. This mechanism operates for reaction schemes which, when modeled using deterministic rate equations, fail to exhibit oscillations for any values of rate constants. The mechanism relies on amplification of the underlying stochasticity of reaction kinetics within a narrow window of frequencies. This amplification means that fluctuations have a dominant effect, even though the number of molecules in the system is relatively large. The mechanism is quantitatively studied within simple models of self-regulatory gene expression, and glycolytic oscillations.
UR - http://www.scopus.com/inward/record.url?scp=34249937560&partnerID=8YFLogxK
U2 - 10.1007/s10955-006-9221-9
DO - 10.1007/s10955-006-9221-9
M3 - Article
AN - SCOPUS:34249937560
SN - 0022-4715
VL - 128
SP - 165
EP - 191
JO - Journal of Statistical Physics
JF - Journal of Statistical Physics
IS - 1-2
ER -