An active DNA-based nanoprobe for photoacoustic pH imaging

Kevin N. Baumann; Alexandra C. Fux; James Joseph; Sarah E. Bohndiek; Silvia Hernández-Ainsa

doi:10.1039/c8cc04007a

An active DNA-based nanoprobe for photoacoustic pH imaging

Kevin N. Baumann, Alexandra C. Fux, James Joseph, Sarah E. Bohndiek, Silvia Hernández-Ainsa

Biomedical Engineering

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6 Citations (Scopus)

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Abstract

We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.

Original language	English
Pages (from-to)	10176-10178
Number of pages	3
Journal	Chemical Communications
Volume	54
Issue number	72
Early online date	23 Aug 2018
DOIs	https://doi.org/10.1039/c8cc04007a
Publication status	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c8cc04007aLicence: CC BY

Final Published VersionFinal published version, 1.75 MBLicence: CC BY

Cite this

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abstract = "We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.",

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AU - Hernández-Ainsa, Silvia

PY - 2018

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AB - We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.

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An active DNA-based nanoprobe for photoacoustic pH imaging

Abstract

ASJC Scopus subject areas

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