An active DNA-based nanoprobe for photoacoustic pH imaging

Kevin N. Baumann, Alexandra C. Fux, James Joseph, Sarah E. Bohndiek, Silvia Hernández-Ainsa

Research output: Contribution to journalArticle

1 Citation (Scopus)
4 Downloads (Pure)

Abstract

We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.

Original languageEnglish
Pages (from-to)10176-10178
Number of pages3
JournalChemical Communications
Volume54
Issue number72
Early online date23 Aug 2018
DOIs
Publication statusPublished - 2018

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