An additional role for SUMO in ubiquitin-mediated proteolysis

Marie-Claude Geoffroy, Ronald T. Hay

    Research output: Contribution to journalReview article

    179 Citations (Scopus)

    Abstract

    Although the post-translational modification of proteins with small ubiquitin-like modifier (SUMO) has a role in many biological processes, it was thought that SUMO, unlike ubiquitin, does not target proteins for degradation. However, these views need to be revised, as recent findings in yeast and human cells indicate that SUMO can act as a signal for the recruitment of E3 ubiquitin ligases, which leads to the ubiquitylation and degradation of the modified protein.

    Original languageEnglish
    Pages (from-to)564-568
    Number of pages5
    JournalNature Reviews Molecular Cell Biology
    Volume10
    Issue number8
    DOIs
    Publication statusPublished - Aug 2009

    Keywords

    • ACUTE PROMYELOCYTIC LEUKEMIA
    • TRIOXIDE-INDUCED APOPTOSIS
    • NUCLEAR-PORE COMPLEX
    • RAR-ALPHA
    • SACCHAROMYCES-CEREVISIAE
    • IN-VITRO
    • PML
    • PROTEIN
    • RNF4
    • LIGASE

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