An additional role for SUMO in ubiquitin-mediated proteolysis

TY - JOUR

T1 - An additional role for SUMO in ubiquitin-mediated proteolysis

AU - Geoffroy, Marie-Claude

AU - Hay, Ronald T.

PY - 2009/8

Y1 - 2009/8

N2 - Although the post-translational modification of proteins with small ubiquitin-like modifier (SUMO) has a role in many biological processes, it was thought that SUMO, unlike ubiquitin, does not target proteins for degradation. However, these views need to be revised, as recent findings in yeast and human cells indicate that SUMO can act as a signal for the recruitment of E3 ubiquitin ligases, which leads to the ubiquitylation and degradation of the modified protein.

AB - Although the post-translational modification of proteins with small ubiquitin-like modifier (SUMO) has a role in many biological processes, it was thought that SUMO, unlike ubiquitin, does not target proteins for degradation. However, these views need to be revised, as recent findings in yeast and human cells indicate that SUMO can act as a signal for the recruitment of E3 ubiquitin ligases, which leads to the ubiquitylation and degradation of the modified protein.

KW - ACUTE PROMYELOCYTIC LEUKEMIA

KW - TRIOXIDE-INDUCED APOPTOSIS

KW - NUCLEAR-PORE COMPLEX

KW - RAR-ALPHA

KW - SACCHAROMYCES-CEREVISIAE

KW - IN-VITRO

KW - PML

KW - PROTEIN

KW - RNF4

KW - LIGASE

U2 - 10.1038/nrm2707

DO - 10.1038/nrm2707

M3 - Review article

C2 - 19474794

SN - 1471-0072

VL - 10

SP - 564

EP - 568

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 8

ER -