An animal paired crossover ePTFE arteriovenous graft model

TY - JOUR

T1 - An animal paired crossover ePTFE arteriovenous graft model

AU - Jahrome, Abdelkarime K.

AU - Hoefer, Imo

AU - Moll, Frans L.

AU - Houston, Graeme J.

AU - Stonebridge, Peter A.

AU - Blankestijn, Peter J.

AU - De Borst, Gert J.

N1 - Copyright 2011 Elsevier B.V., All rights reserved.

PY - 2010/11/29

Y1 - 2010/11/29

N2 - Purpose: Previously, we developed a porcine model for Arterio Venous Graft (AVG) failure to allow assessment of new access strategies. This model was limited concerning graft length. In the present technical report, we describe a modification of our model allowing the assessment of long AVGs.Technique: In 4 pigs, AVGs of 15 cm length were created bilaterally in a cross-over fashion between the carotid artery and the contralateral jugular vein. Two days (2 pigs) and two weeks (2 pigs) after AV shunting, graft patency was evaluated by angiography, showing all four grafts to be patent, with no sign of angiographic or macroscopic narrowing at the anastomoses sites.Conclusions: In this modified pig AVG failure model, implantation of a bilateral cross-over long AVG is a feasible approach. The present model offers a suitable tool to study local interventions or compare various long graft designs aimed at improvement of AVG patency.

AB - Purpose: Previously, we developed a porcine model for Arterio Venous Graft (AVG) failure to allow assessment of new access strategies. This model was limited concerning graft length. In the present technical report, we describe a modification of our model allowing the assessment of long AVGs.Technique: In 4 pigs, AVGs of 15 cm length were created bilaterally in a cross-over fashion between the carotid artery and the contralateral jugular vein. Two days (2 pigs) and two weeks (2 pigs) after AV shunting, graft patency was evaluated by angiography, showing all four grafts to be patent, with no sign of angiographic or macroscopic narrowing at the anastomoses sites.Conclusions: In this modified pig AVG failure model, implantation of a bilateral cross-over long AVG is a feasible approach. The present model offers a suitable tool to study local interventions or compare various long graft designs aimed at improvement of AVG patency.

UR - https://www.scopus.com/pages/publications/78649338587

U2 - 10.1186/1750-1164-4-7

DO - 10.1186/1750-1164-4-7

M3 - Article

AN - SCOPUS:78649338587

SN - 1750-1164

VL - 4

JO - Annals of Surgical Innovation and Research

JF - Annals of Surgical Innovation and Research

ER -