An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes

Ching-Kim Tye, Ganasan Kasinathan, Michael P. Barrett, Reto Brun, Valerie E. Doyle, Alan H. Fairlamb, Richard Weaver, Ian H. Gilbert

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    Abstract

    In this paper we describe an approach to selectively deliver compounds to trypanosomes using an adenosine transporter which is unique to the trypanosome. Various polyamine analogues have been attached to known substrates of this adenosine transporter. The compounds prepared interact specifically with the adenosine transporter, some with a similar efficiency to berenil, a known substrate. (C) 1998 Elsevier Science Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)811-816
    Number of pages6
    JournalBioorganic & Medicinal Chemistry Letters
    Volume8
    Issue number7
    DOIs
    Publication statusPublished - 7 Apr 1998

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