@article{3bfa1516ee844a8fba14fbd08c43f342,
title = "An early developmental vertebrate model for nanomaterial safety: Bridging cell-based and mammalian toxicity assessment",
abstract = "Aim: With the rise in production of nanoparticles (NPs) for an ever-increasing number of applications, there is an urgent need to efficiently assess their potential toxicity. We propose a NP hazard assessment protocol that combines mammalian cytotoxicity data with embryonic vertebrate abnormality scoring to determine an overall toxicity index. Results: We observed that, after exposure to a range of NPs, Xenopus phenotypic scoring showed a strong correlation with cell based in vitro assays. Magnetite-cored NPs, negative for toxicity in vitro and Xenopus, were further confirmed as nontoxic in mice. Conclusion: The results highlight the potential of Xenopus embryo analysis as a fast screening approach for toxicity assessment of NPs, which could be introduced for the routine testing of nanomaterials.",
keywords = "cytotoxicity, in vitro-in vivo correlations, nanomaterials, nanomedicine, nanotoxicity, Xenopus laevis",
author = "Webster, {Carl A.} and {Di Silvio}, Desire and Aarthi Devarajan and Paolo Bigini and Edoardo Micotti and Chiara Giudice and Mario Salmona and Wheeler, {Grant N.} and Victoria Sherwood and Bombelli, {Francesca Baldelli}",
note = "This work was supported by funds from The British Skin Foundation, The Royal Society and UEA start up funds to V Sherwood and FB Bombelli. FB Bombelli would like to thank for additional financial support RegioneLombardia (Fondo per lo Sviluppo e la Coesione - FAS 2007–2013). V Sherwood is supported by a CRUK programme grant awarded to the CRUKSkin Tumour Laboratory, Medical School, University of Dundee. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed",
year = "2016",
month = mar,
doi = "10.2217/nnm.15.219",
language = "English",
volume = "11",
pages = "643--656",
journal = "Nanomedicine",
issn = "1743-5889",
publisher = "Future Medicine",
number = "6",
}