An efficient and versatile synthesis of GlcNAcstatins-potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold

Keyphrases

• O-GlcNAcase 100%
• Imidazole 100%
• Pyridine Scaffold 100%
• Potent Inhibitor 50%
• Protecting Groups 50%
• Methyl 50%
• Thiols 50%
• Selective Inhibitor 50%
• Acyl 50%
• Mannose 50%
• Amido 50%
• Ammonia 50%
• Monosaccharides 50%
• Mannopyranosides 50%
• Acid-labile 50%
• Ring Closure 50%
• Excellent Yields 50%
• Glyoxal 50%
• Aldehydes 50%
• Synthetic Sequences 50%
• Compound Bearing 50%

Chemistry

• Imidazole 100%
• Protecting Groups 50%
• Monosaccharide 50%
• Glyoxal 50%
• D-Mannose 50%
• Thiol 50%
• Aldehyde 50%