TY - JOUR
T1 - An efficient synthesis of argifin
T2 - a natural product chitinase inhibitor with chemotherapeutic potential
AU - Dixon, Mark J.
AU - Andersen, Ole A.
AU - van Aalten, Daan M. F.
AU - Eggleston, Ian M.
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2005/11/1
Y1 - 2005/11/1
N2 - The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.
AB - The first synthesis of the cyclopentapeptide family 18 chitinase inhibitor argifin has been achieved by a combination of solid phase and solution chemistry. Synthetic argifin is a nanomolar inhibitor of chitinase B1 from Aspergillus fumigatus and the high-resolution X-ray structure of the synthesized material in complex with the same enzyme is identical to that previously obtained for the natural product.
UR - http://www.scopus.com/inward/record.url?scp=25444507108&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2005.07.068
DO - 10.1016/j.bmcl.2005.07.068
M3 - Article
AN - SCOPUS:25444507108
SN - 0960-894X
VL - 15
SP - 4717
EP - 4721
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
IS - 21
ER -