AN EVALUATION OF THE POTENTIAL INTERACTION BETWEEN ENALAPRIL AND AMILORIDE

Enalapril was shown to have no effect on the serum potassium of patients (n= 16) already taking Frusemide and Amiloride. Furthermore, there was no difference in serum potassium levels of the group taking a combination of Enalapril, Frusemide and Amiloride when compared to a similar group of patients taking Frusemide and Amiloride alone (n= 19). No patients in either group were deemed to have seriously impaired renal function.

The results indicate that the theoretical hyperkalaemic effect of concurrent administration of Enalapril and Amiloride is not manifest in clinical practice in patients with normal renal function.