An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

Anthony R. Butler; Robert A. Field; Iain R. Greig; Frederick W. Flitney; Stuart K. Bisland; Faisel Khan; Jill J.F. Belch

doi:10.1006/niox.1997.0125

An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

Anthony R. Butler, Robert A. Field, Iain R. Greig, Frederick W. Flitney, Stuart K. Bisland, Faisel Khan, Jill J.F. Belch

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.

Original language	English
Pages (from-to)	211-217
Number of pages	7
Journal	Nitric Oxide
Volume	1
Issue number	3
DOIs	https://doi.org/10.1006/niox.1997.0125
Publication status	Published - Jun 1997

Keywords

NITRIC-OXIDE
S-NITROSOTHIOLS
INHIBITION

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10.1006/niox.1997.0125

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title = "An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators",

abstract = "A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.",

keywords = "NITRIC-OXIDE, S-NITROSOTHIOLS, INHIBITION",

author = "Butler, {Anthony R.} and Field, {Robert A.} and Greig, {Iain R.} and Flitney, {Frederick W.} and Bisland, {Stuart K.} and Faisel Khan and Belch, {Jill J.F.}",

year = "1997",

month = jun,

doi = "10.1006/niox.1997.0125",

language = "English",

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pages = "211--217",

journal = "Nitric Oxide",

issn = "1089-8603",

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T1 - An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

AU - Butler, Anthony R.

AU - Field, Robert A.

AU - Greig, Iain R.

AU - Flitney, Frederick W.

AU - Bisland, Stuart K.

AU - Khan, Faisel

AU - Belch, Jill J.F.

PY - 1997/6

Y1 - 1997/6

N2 - A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.

AB - A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.

KW - NITRIC-OXIDE

KW - S-NITROSOTHIOLS

KW - INHIBITION

U2 - 10.1006/niox.1997.0125

DO - 10.1006/niox.1997.0125

M3 - Article

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VL - 1

SP - 211

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JO - Nitric Oxide

JF - Nitric Oxide

IS - 3

ER -

An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

Abstract

Keywords

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