An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

Anthony R. Butler, Robert A. Field, Iain R. Greig, Frederick W. Flitney, Stuart K. Bisland, Faisel Khan, Jill J.F. Belch

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.

    Original languageEnglish
    Pages (from-to)211-217
    Number of pages7
    JournalNitric Oxide Biology and Chemistry
    Volume1
    Issue number3
    DOIs
    Publication statusPublished - Jun 1997

    Keywords

    • NITRIC-OXIDE
    • S-NITROSOTHIOLS
    • INHIBITION

    Cite this

    Butler, Anthony R. ; Field, Robert A. ; Greig, Iain R. ; Flitney, Frederick W. ; Bisland, Stuart K. ; Khan, Faisel ; Belch, Jill J.F. / An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators. In: Nitric Oxide Biology and Chemistry. 1997 ; Vol. 1, No. 3. pp. 211-217.
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    abstract = "A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.",
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    year = "1997",
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    An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators. / Butler, Anthony R.; Field, Robert A.; Greig, Iain R.; Flitney, Frederick W.; Bisland, Stuart K.; Khan, Faisel; Belch, Jill J.F.

    In: Nitric Oxide Biology and Chemistry, Vol. 1, No. 3, 06.1997, p. 211-217.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

    AU - Butler, Anthony R.

    AU - Field, Robert A.

    AU - Greig, Iain R.

    AU - Flitney, Frederick W.

    AU - Bisland, Stuart K.

    AU - Khan, Faisel

    AU - Belch, Jill J.F.

    PY - 1997/6

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    AB - A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.

    KW - NITRIC-OXIDE

    KW - S-NITROSOTHIOLS

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