An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators

Anthony R. Butler, Robert A. Field, Iain R. Greig, Frederick W. Flitney, Stuart K. Bisland, Faisel Khan, Jill J.F. Belch

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    23 Citations (Scopus)

    Abstract

    A number of S-nitrosated compounds derived from l-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized, Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally. (C) 1997 Academic Press.

    Original languageEnglish
    Pages (from-to)211-217
    Number of pages7
    JournalNitric Oxide Biology and Chemistry
    Volume1
    Issue number3
    DOIs
    Publication statusPublished - Jun 1997

    Keywords

    • NITRIC-OXIDE
    • S-NITROSOTHIOLS
    • INHIBITION

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