An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing

Patricia Soares (Lead / Corresponding author), Katy Fidler, Jessie Felton, Christina J. Jones, Roger Tavendale, Anke Hövels, Stephen Bremner, Colin N. A. Palmer, Somnath Mukhopadhyay

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Abstract

The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).

Original languageEnglish
Pages (from-to)1089-1092
Number of pages4
JournalClinical and Experimental Allergy
Volume51
Issue number8
Early online date29 May 2021
DOIs
Publication statusPublished - Aug 2021

Keywords

  • asthma
  • atopic dermatitis
  • pharmacogenomics
  • pharmacology
  • rhinitis
  • Immunology
  • Immunology and Allergy

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