Abstract
The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).
Original language | English |
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Pages (from-to) | 1089-1092 |
Number of pages | 4 |
Journal | Clinical and Experimental Allergy |
Volume | 51 |
Issue number | 8 |
Early online date | 29 May 2021 |
DOIs | |
Publication status | Published - Aug 2021 |
Keywords
- asthma
- atopic dermatitis
- pharmacogenomics
- pharmacology
- rhinitis
- Immunology
- Immunology and Allergy
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology