An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing

Patricia Soares; Katy Fidler; Jessie Felton; Christina J. Jones; Roger Tavendale; Anke Hövels; Stephen Bremner; Colin N. A. Palmer; Somnath Mukhopadhyay

doi:10.1111/cea.13958

An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing

Patricia Soares (Lead / Corresponding author), Katy Fidler, Jessie Felton, Christina J. Jones, Roger Tavendale, Anke Hövels, Stephen Bremner, Colin N. A. Palmer, Somnath Mukhopadhyay

Population Health and Genomics

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Abstract

The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).

Original language	English
Pages (from-to)	1089-1092
Number of pages	4
Journal	Clinical and Experimental Allergy
Volume	51
Issue number	8
Early online date	29 May 2021
DOIs	https://doi.org/10.1111/cea.13958
Publication status	Published - Aug 2021

Keywords

asthma
atopic dermatitis
pharmacogenomics
pharmacology
rhinitis
Immunology
Immunology and Allergy

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1111/cea.13958Licence: CC BY

Author Accepted ManuscriptAccepted author manuscript, 5.41 MB
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Cite this

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title = "An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing",

abstract = "The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).",

keywords = "asthma, atopic dermatitis, pharmacogenomics, pharmacology, rhinitis, Immunology, Immunology and Allergy",

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year = "2021",

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AU - Soares, Patricia

AU - Fidler, Katy

AU - Felton, Jessie

AU - Jones, Christina J.

AU - Tavendale, Roger

AU - Hövels, Anke

AU - Bremner, Stephen

AU - Palmer, Colin N. A.

AU - Mukhopadhyay, Somnath

PY - 2021/8

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AB - The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).

KW - asthma

KW - atopic dermatitis

KW - pharmacogenomics

KW - pharmacology

KW - rhinitis

KW - Immunology

KW - Immunology and Allergy

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An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing

Abstract

Keywords

ASJC Scopus subject areas

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