An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing

Patricia Soares; Katy Fidler; Jessie Felton; Christina J. Jones; Roger Tavendale; Anke Hövels; Stephen Bremner; Colin N. A. Palmer; Somnath Mukhopadhyay

doi:10.1111/cea.13958

An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing

Patricia Soares (Lead / Corresponding author)
, Katy Fidler
, Jessie Felton
, Christina J. Jones
, Roger Tavendale
, Anke Hövels
, Stephen Bremner
, Colin N. A. Palmer
, Somnath Mukhopadhyay

Population Health and Genomics

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

185 Downloads (Pure)

Abstract

The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).

Original language	English
Pages (from-to)	1089-1092
Number of pages	4
Journal	Clinical and Experimental Allergy
Volume	51
Issue number	8
Early online date	29 May 2021
DOIs	https://doi.org/10.1111/cea.13958
Publication status	Published - Aug 2021

Keywords

asthma
atopic dermatitis
pharmacogenomics
pharmacology
rhinitis
Immunology
Immunology and Allergy

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1111/cea.13958Licence: CC BY

Author Accepted ManuscriptAccepted author manuscript, 5.41 MB
Final Published VersionFinal published version, 233 KBLicence: CC BY

Cite this

@article{f7ce3342b7c5491bbc6f16d318601377,

title = "An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing",

abstract = "The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).",

keywords = "asthma, atopic dermatitis, pharmacogenomics, pharmacology, rhinitis, Immunology, Immunology and Allergy",

author = "Patricia Soares and Katy Fidler and Jessie Felton and Jones, \{Christina J.\} and Roger Tavendale and Anke H{\"o}vels and Stephen Bremner and Palmer, \{Colin N. A.\} and Somnath Mukhopadhyay",

year = "2021",

month = aug,

doi = "10.1111/cea.13958",

language = "English",

volume = "51",

pages = "1089--1092",

journal = "Clinical and Experimental Allergy",

issn = "0954-7894",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing

AU - Soares, Patricia

AU - Fidler, Katy

AU - Felton, Jessie

AU - Jones, Christina J.

AU - Tavendale, Roger

AU - Hövels, Anke

AU - Bremner, Stephen

AU - Palmer, Colin N. A.

AU - Mukhopadhyay, Somnath

PY - 2021/8

Y1 - 2021/8

N2 - The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).

AB - The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT).

KW - asthma

KW - atopic dermatitis

KW - pharmacogenomics

KW - pharmacology

KW - rhinitis

KW - Immunology

KW - Immunology and Allergy

UR - https://www.scopus.com/pages/publications/85107565003

U2 - 10.1111/cea.13958

DO - 10.1111/cea.13958

M3 - Article

C2 - 34050993

SN - 0954-7894

VL - 51

SP - 1089

EP - 1092

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

IS - 8

ER -

An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this