An imino-linked carba-disaccharide α-D-mannosidase inhibitor

TY - JOUR

T1 - An imino-linked carba-disaccharide α-D-mannosidase inhibitor

AU - Cottaz, Sylvain

AU - Brimacombe, John S.

AU - Ferguson, Michael A. J.

N1 - Medline is the source for the MeSH terms of this document.

PY - 1993/9/2

Y1 - 1993/9/2

N2 - In connection with a project concerned with inhibition of the biosynthesis of glycosyl phophatidylinositol (GPI) anchors, we had occasion to synthesise the unsaturated (1?6)-imino-linked carba-disaccharide 2 having the `A-manno' configuration, which was also tested as a potential inhibitor of A-D-mannosidase and other glycosidases. The results of these tests and a synthesis of 2 are reported herein.

AB - In connection with a project concerned with inhibition of the biosynthesis of glycosyl phophatidylinositol (GPI) anchors, we had occasion to synthesise the unsaturated (1?6)-imino-linked carba-disaccharide 2 having the `A-manno' configuration, which was also tested as a potential inhibitor of A-D-mannosidase and other glycosidases. The results of these tests and a synthesis of 2 are reported herein.

UR - https://www.scopus.com/pages/publications/0027906299

U2 - 10.1016/0008-6215(93)84269-C

DO - 10.1016/0008-6215(93)84269-C

M3 - Article

AN - SCOPUS:0027906299

SN - 0008-6215

VL - 247

SP - 341

EP - 345

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -