An in vivo analysis of the localisation and interactions of human p66 DNA polymerase δ subunit

J Richard G. Pohler, Marit Otterlei, Emma Warbrick

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    DNA polymerase d is essential for eukaryotic DNA replication and also plays a role in DNA repair. The processivity of this polymerase complex is dependent upon its interaction with the sliding clamp PCNA and the polymerase-PCNA interaction is largely mediated through the p66 polymerase subunit. We have analysed the interactions of the human p66 DNA polymerase d subunit with PCNA and with components of the DNA polymerase d complex in vivo.
    Original languageEnglish
    Pages (from-to)17-30
    Number of pages14
    JournalBMC Molecular Biology
    Issue number1
    Publication statusPublished - 2005


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