An in vivo model for overloading-induced soft tissue injury

Panagiotis E. Chatzistergos; Nachiappan Chockalingam

doi:10.1038/s41598-022-10011-7

An in vivo model for overloading-induced soft tissue injury

Panagiotis E. Chatzistergos (Lead / Corresponding author), Nachiappan Chockalingam

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

12 Downloads (Pure)

Abstract

This proof-of-concept study demonstrates that repetitive loading to the pain threshold can safely recreate overloading-induced soft tissue damage and that localised tissue stiffening can be a potential marker for injury. This concept was demonstrated here for the soft tissue of the sole of the foot where it was found that repeated loading to the pain threshold led to long-lasting statistically significant stiffening in the overloaded areas. Loading at lower magnitudes did not have the same effect. This method can shed new light on the aetiology of overloading injury in the foot to improve the management of conditions such as diabetic foot ulceration and heel pain syndrome. Moreover, the link between overloading and tissue stiffening, which was demonstrated here for the first time for the plantar soft tissue, opens the way for an assessment of overloading thresholds that is not based on the subjective measurement of pain thresholds.

Original language	English
Article number	6047
Number of pages	10
Journal	Scientific Reports
Volume	12
Early online date	11 Apr 2022
DOIs	https://doi.org/10.1038/s41598-022-10011-7
Publication status	E-pub ahead of print - 11 Apr 2022

ASJC Scopus subject areas

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UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-022-10011-7Licence: CC BY

Final published versionFinal published version, 2.19 MBLicence: CC BY

Cite this

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An in vivo model for overloading-induced soft tissue injury

Abstract

ASJC Scopus subject areas

UN SDGs

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