An integrated model-based software for FUS in moving abdominal organs

Michael Schwenke, Jan Strehlow, Sabrina Haase, Juergen Jenne, Christine Tanner, Thomas Langø, Arjo J. Loeve, Ioannis Karakitsios, Xu Xiao, Yoav Levy, Giora Sat, Mario Bezzi, Stefan Braunewell, Matthias Guenther, Andreas Melzer, Tobias Preusser

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Focused ultrasound surgery (FUS) is a non-invasive method for tissue ablation that has the potential for complete and controlled local tumour destruction with minimal side effects. The treatment of abdominal organs such as the liver, however, requires particular technological support in order to enable a safe, efficient and effective treatment. As FUS is applied from outside the patient's body, suitable imaging methods, such as magnetic resonance imaging or diagnostic ultrasound, are needed to guide and track the procedure. To facilitate an efficient FUS procedure in the liver, the organ motion during breathing and the partial occlusion by the rib cage need to be taken into account in real time, demanding a continuous patient-specific adaptation of the treatment configuration. Modelling the patient's respiratory motion and combining this with tracking data improves the accuracy of motion predictions. Modelling and simulation of the FUS effects within the body allows the use of treatment planning and has the potential to be used within therapy to increase knowledge about the patient status. This article describes integrated model-based software for patient-specific modelling and prediction for FUS treatments of moving abdominal organs.

Original languageEnglish
Pages (from-to)240-250
Number of pages11
JournalInternational Journal of Hyperthermia
Volume31
Issue number3
Early online date19 Mar 2015
DOIs
Publication statusPublished - 2015

Keywords

  • Clinical trials-thermal ablation
  • High-intensity focused ultrasound
  • Modelling
  • Thermal ablation

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    Schwenke, M., Strehlow, J., Haase, S., Jenne, J., Tanner, C., Langø, T., Loeve, A. J., Karakitsios, I., Xiao, X., Levy, Y., Sat, G., Bezzi, M., Braunewell, S., Guenther, M., Melzer, A., & Preusser, T. (2015). An integrated model-based software for FUS in moving abdominal organs. International Journal of Hyperthermia , 31(3), 240-250. https://doi.org/10.3109/02656736.2014.1002817