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An integrative computational model for intestinal tissue renewal
I. M.M. Van Leeuwen
, G. R. Mirams
, A. Walter
, A. Fletcher
,
P. J. Murray
, J. Osborne
, S. Varma
, S. J. Young
, J. Cooper
, B. Doyle
, J. Pitt-Francis
, L. Momtahan
, P. Pathmanathan
, J. P. Whiteley
,
S. J. Chapman
, D. J. Gavaghan
, O. E. Jensen
, J. R. King
, P. K. Maini
, S. L. Waters
H. M. Byrne
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Mathematics
Research output
:
Contribution to journal
›
Article
›
peer-review
136
Citations (Scopus)
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Keyphrases
Computational Model
100%
Intestinal Tissue
100%
Crypt
100%
Tissue Renewal
100%
Clonal Expansion
50%
Epithelial Cells
50%
Subcellular Level
50%
Stem Cells
25%
Epithelium
25%
Therapeutic Intervention
25%
Cellular Level
25%
Wnt Signaling
25%
Neoplasia
25%
Cell Cycle Control
25%
Protective Barrier
25%
Extracellular Products
25%
Mutation Data
25%
Tissue Level
25%
Potential Therapeutics
25%
Labeling Index
25%
Cell Position
25%
Control Signal
25%
Molecular Network
25%
Levels of Organization
25%
Model Extension
25%
Deterministic Model
25%
Nuclear β-catenin
25%
Mitochondrial DNA mutation
25%
Loss of Homeostasis
25%
Renewal Process
25%
Virtual Microdissection
25%
Extracellular Cues
25%
Biochemistry, Genetics and Molecular Biology
Dynamics
100%
Homeostasis
100%
Beta-Catenin
100%
Wnt Signaling Pathway
100%
Cell Cycle Regulation
100%
Stem Cell
100%
Tissue Level
100%
DNA Mutation
100%
Microdissection
100%
Molecular Network
100%
Mitochondrial DNA
100%
Engineering
Subcellular
100%
Renewals
100%
Spatial Variation
50%
Multiscale Model
50%
Powerful Tool
50%
Dysfunction
50%
Test Hypothesis
50%
Control Cycle
50%
Renewal Process
50%
Monolayers
50%
Stem Cell
50%