Background: Clinical teaching for many years has been to assume that diabetic ketoacidosis is pathognomic of type 1 diabetes. However, this dogma is now increasingly questioned as increasing numbers of people are admitted with diabetic ketoacidosis without the typical features of autoimmune type 1 diabetes. Such individuals are increasingly diagnosed with ketosis-prone diabetes, a heterogenous syndrome where individuals present with diabetic ketoacidosis or unprovoked ketosis but are usually autoantibody negative and have no residual ß-cell function. Classification of ketosis-prone diabetes using the Aß system can aid in diagnosis and treatment decisions.
Gardiner, A., George, P. S., Pearson, E., & McCrimmon, R. J. (2013). An interesting case of new-onset ketosis-prone diabetes in a Scottish teaching hospital. British Journal of Diabetes and Vascular Disease, 13(5-6), 265-268. https://doi.org/10.1177/1474651413503891